دورية أكاديمية
Neurocognitive function and delusion severity in schizophrenia spectrum disorders.
| العنوان: | Neurocognitive function and delusion severity in schizophrenia spectrum disorders. |
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| المؤلفون: | Mohn C; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway; National Centre for Suicide Research and Prevention, Institute of Clinical Medicine, University of Oslo, Norway. Electronic address: h.c.mohn@medisin.uio.no., Ueland T; Norwegian Centre for Mental Disorders Research, Psychosis Research Section, Division of Mental Health and Addiction, Oslo University Hospital, Norway; Department of Psychology, University of Oslo, Norway., Haatveit B; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway; Norwegian Centre for Mental Disorders Research, Psychosis Research Section, Division of Mental Health and Addiction, Oslo University Hospital, Norway., Sæther LS; Norwegian Centre for Mental Disorders Research, Psychosis Research Section, Division of Mental Health and Addiction, Oslo University Hospital, Norway; Department of Psychology, University of Oslo, Norway., Lagerberg TV; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway; Norwegian Centre for Mental Disorders Research, Psychosis Research Section, Division of Mental Health and Addiction, Oslo University Hospital, Norway., Andreassen OA; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway; Norwegian Centre for Mental Disorders Research, Psychosis Research Section, Division of Mental Health and Addiction, Oslo University Hospital, Norway., Melle I; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway; National Centre for Suicide Research and Prevention, Institute of Clinical Medicine, University of Oslo, Norway., Vaskinn A; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Norway; Centre for Research and Education in Forensic Psychiatry, Oslo University Hospital, Norway. |
| المصدر: | Schizophrenia research [Schizophr Res] 2024 Aug; Vol. 270, pp. 172-177. Date of Electronic Publication: 2024 Jun 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988- |
| مواضيع طبية MeSH: | Schizophrenia*/physiopathology , Schizophrenia*/complications , Delusions*/etiology , Delusions*/physiopathology, Humans ; Male ; Female ; Adult ; Middle Aged ; Neuropsychological Tests ; Psychotic Disorders/physiopathology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Severity of Illness Index ; Schizophrenic Psychology ; Intelligence/physiology |
| مستخلص: | The role of basic neurocognitive function in delusions is unclear despite the association to difficulties in reasoning and decision-making. We investigated 812 individuals with schizophrenia spectrum disorders (SSD) using a broad neuropsychological test battery encompassing motor and mental processing speed, working memory, learning and memory, and executive function. Premorbid and current intellectual function was assessed with NART and WASI. Delusion level and other clinical symptoms were measured with the PANSS and GAF. Hierarchical and k-means cluster analysis using standardized scores showed the presence of two separate clusters where the group with the higher delusion level (n = 291) was characterized by more severe neurocognitive deficits (>1.5 standard deviations below the healthy control mean), higher PANSS scores, lower GAF scores, and lower intelligence levels compared to the cluster with mild impairments (n = 521). We conclude that a higher delusion level is related to neurocognitive deficits across domains. Further, the validity of the two separate clusters was indicated by significant differences in clinical symptoms, everyday function, and intellectual ability. Compared to those with mild delusion levels, SSD patients with higher delusion levels seem particularly disadvantaged, with co-occurring general symptoms and lower daily function, underscoring the need for clinical and psychosocial support programs. A limitation of this study is the cross sectional design. Longitudinal studies are needed to determine the causal relationship between delusions and neurocognitive function. Competing Interests: Declaration of competing interest None. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cognition; Delusions; Neurocognition; Psychosis; Schizophrenia |
| تواريخ الأحداث: | Date Created: 20240625 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1016/j.schres.2024.06.028 |
| PMID: | 38917554 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2509 |
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| DOI: | 10.1016/j.schres.2024.06.028 |