دورية أكاديمية
Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice.
| العنوان: | Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice. |
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| المؤلفون: | Zheng QX; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China., Liu QL; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China., Sun WN; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China., Jiang XY; School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China., Zeng T; Institute of Toxicology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: zengtao@sdu.edu.cn. |
| المصدر: | Toxicology [Toxicology] 2024 Aug; Vol. 506, pp. 153872. Date of Electronic Publication: 2024 Jun 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam. Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Dimethylformamide*/toxicity , Ethanol*/toxicity , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/etiology , Chemical and Drug Induced Liver Injury*/metabolism , Cytochrome P-450 CYP2E1*/metabolism , Liver*/drug effects , Liver*/pathology , Liver*/metabolism , Alcohol Drinking*/adverse effects, Animals ; Mice ; Male ; Apoptosis/drug effects ; Alanine Transaminase/blood ; Aspartate Aminotransferases/blood ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Dose-Response Relationship, Drug ; Inflammasomes/metabolism ; Inflammasomes/drug effects ; Mice, Inbred C57BL |
| مستخلص: | N,N-Dimethylformamide (DMF) is a well-documented occupational hazardous material, which can induce occupational liver injury. The current study was designed to investigate whether ethanol consumption can affect DMF-induced hepatotoxicity and the potential underlying mechanisms involved. We found that a single dose of ethanol (1.25, 2.5, or 5 g/kg bw by gavage) significantly repressed the increase in serum alanine transaminase (ALT) and aspartate transaminase (AST) activities and alleviated the liver histopathological changes in mice challenged with 3 g/kg DMF. In contrast, long-term moderate drinking (2.5 g/kg bw) significantly aggravated the repeated DMF (0.7 g/kg bw) exposure-induced increase in the serum ALT and AST activities. Mechanistically, acute ethanol consumption suppressed DMF-induced activation of the NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome, while long-term moderate ethanol consumption promoted hepatocyte apoptosis in the mouse liver. Notably, cytochrome P4502E1 (CYP2E1) protein level and activity in mouse livers were not significantly affected by ethanol per se in the two models. These results confirm that regular drinking can increase the risk of DMF-induced hepatotoxicity, and suggest that DMF-handling workers should avoid consuming ethanol to reduce the risk of DMF-indued liver injury. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Apoptosis; Cytochrome P4502E1; N,N-Dimethylformamide; NLRP3 inflammasome; Occupational liver disease |
| المشرفين على المادة: | 8696NH0Y2X (Dimethylformamide) 3K9958V90M (Ethanol) EC 1.14.13.- (Cytochrome P-450 CYP2E1) EC 2.6.1.2 (Alanine Transaminase) EC 2.6.1.1 (Aspartate Aminotransferases) 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (Nlrp3 protein, mouse) EC 1.14.13.- (cytochrome P-450 2E1, mouse) 0 (Inflammasomes) |
| تواريخ الأحداث: | Date Created: 20240626 Date Completed: 20240722 Latest Revision: 20240722 |
| رمز التحديث: | 20240723 |
| DOI: | 10.1016/j.tox.2024.153872 |
| PMID: | 38924947 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-3185 |
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| DOI: | 10.1016/j.tox.2024.153872 |