دورية أكاديمية
أعرض في EDS

Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice.

التفاصيل البيبلوغرافية
العنوان: Brain-derived neurotrophic factor contributes to activity-induced muscle pain in male but not female mice.
المؤلفون: Hayashi K; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA; Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Lesnak JB; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA., Plumb AN; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA., Janowski AJ; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA., Smith AF; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA., Hill JK; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA., Sluka KA; Department of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa City, IA, USA. Electronic address: kathleen-sluka@uiowa.edu.
المصدر: Brain, behavior, and immunity [Brain Behav Immun] 2024 Aug; Vol. 120, pp. 471-487. Date of Electronic Publication: 2024 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: San Diego : Academic Press, [c1987-
مواضيع طبية MeSH: Brain-Derived Neurotrophic Factor*/metabolism , Ganglia, Spinal*/metabolism , Interleukin-1beta*/metabolism , Myalgia*/metabolism , Hyperalgesia*/metabolism, Animals ; Male ; Female ; Mice ; Mice, Inbred C57BL ; Receptor, trkB/metabolism ; Muscle, Skeletal/metabolism ; Sex Factors ; Sex Characteristics ; Benzamides/pharmacology ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/drug effects ; Azepines
مستخلص: Activity-induced muscle pain increases interleukin-1β (IL-1β) release from muscle macrophages and the development of hyperalgesia is prevented by blockade of IL-1β in muscle. Brain derived neurotrophic factor (BDNF) is released from sensory neurons in response to IL-1β and mediates both inflammatory and neuropathic pain. Thus, we hypothesize that in activity-induced pain, fatigue metabolites combined with IL-1β activate sensory neurons to increase BDNF release, peripherally in muscle and centrally in the spinal dorsal horn, to produce hyperalgesia. We tested the effect of intrathecal or intramuscular injection of BDNF-Tropomyosin receptor kinase B (TrkB) inhibitors, ANA-12 or TrkB-Fc, on development of activity-induced pain. Both inhibitors prevented the hyperalgesia when given before or 24hr after induction of the model in male but not female mice. BDNF messenger ribonucleic acid (mRNA) and protein were significantly increased in dorsal root ganglion (DRG) 24hr after induction of the model in both male and female mice. Blockade of IL-1β in muscle had no effect on the increased BNDF mRNA observed in the activity-induced pain model, while IL-1β applied to cultured DRG significantly induced BDNF expression, suggesting IL-1β is sufficient but not necessary to induce BNDF. Thus, fatigue metabolites, combined with IL-1β, upregulate BDNF in primary DRG neurons in both male and female mice, but contribute to activity-induced pain only in males.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
التعليقات: Update of: bioRxiv. 2023 Nov 02:2023.10.31.565022. doi: 10.1101/2023.10.31.565022. (PMID: 37961342)
فهرسة مساهمة: Keywords: Brain-Derived Neurotrophic Factor; Musculoskeletal Pain; Myalgia; Neurons; Pain
المشرفين على المادة: 0 (Brain-Derived Neurotrophic Factor)
0 (Interleukin-1beta)
0 (ANA 12 compound)
EC 2.7.10.1 (Receptor, trkB)
0 (Bdnf protein, mouse)
0 (Benzamides)
0 (Azepines)
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240725 Latest Revision: 20240729
رمز التحديث: 20240729
DOI: 10.1016/j.bbi.2024.06.019
PMID: 38925417
قاعدة البيانات: MEDLINE
الوصف
تدمد:1090-2139
DOI:10.1016/j.bbi.2024.06.019