دورية أكاديمية
أعرض في EDS

The effect of late presentation on HIV related mortality among adolescents in public hospitals of north showa zone Oromiya, Ethiopia; 2022: a retrospective cohort study.

التفاصيل البيبلوغرافية
العنوان: The effect of late presentation on HIV related mortality among adolescents in public hospitals of north showa zone Oromiya, Ethiopia; 2022: a retrospective cohort study.
المؤلفون: Gabre MK; Department of Public Health, College of Health Sciences, Salale University, Fitche, Ethiopia. misgana0970@gmail.com., Tafesse TB; Department of Pharmacy, College of Health Sciences, Salale University, Fitche, Ethiopia., Geleta LA; Department of Public Health, College of Health Sciences, Salale University, Fitche, Ethiopia., Asfaw CK; Department of Medicine, College of Health Sciences, Salale University, Fitche, Ethiopia., Delelegn HA; Department of Medicine, College of Health Sciences, Salale University, Fitche, Ethiopia.
المصدر: BMC infectious diseases [BMC Infect Dis] 2024 Jun 26; Vol. 24 (1), pp. 644. Date of Electronic Publication: 2024 Jun 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: HIV Infections*/mortality , HIV Infections*/drug therapy , HIV Infections*/epidemiology , Hospitals, Public*, Humans ; Ethiopia/epidemiology ; Adolescent ; Retrospective Studies ; Male ; Female ; Young Adult ; Delayed Diagnosis ; Proportional Hazards Models
مستخلص: Background: Late human immunodeficiency virus (HIV) diagnosis is the most prominent cause of HIV/AIDS-related mortality and also increases the risk of transmission and spread of the disease in society. Adolescents are the most vulnerable population's age group for HIV infection in several settings, but expanding access to early HIV testing remains a challenge. Consequently, a significant proportion of adolescents are still dying of HIV-related causes, and the current study aimed at assessing the effect of late presentation on HIV-related mortality among adolescents living with HIV.
Methods: An institutional-based retrospective cohort study was conducted from August 21-November 21, 2022, at selected public hospitals in the North Showa Zone of Oromiya, Ethiopia. All adolescents living with HIV who had received no ART and presented for ART follow-up at public hospitals from September 1, 2012, to August 31, 2021, were included in the study. Data entry was done by Epi-data version 3.1.1 software and exported to Stata version 16 for further analysis. Both bi-variable and multivariable analyses were performed using the Cox proportional hazard model to compare the HIV-related mortality of early and late-presented adolescents using an adjusted hazard ratio at a 95% confidence interval (CI).
Results: A total of 341 medical records of adolescents were included in the study, contributing an overall incidence rate of 3.15 (95% CI: 2.21-4.26) deaths per 100 person-years of observation throughout the total follow-up period of 1173.98 person-years. Adolescents with late presentation for HIV care had three times the higher hazard of mortality (adjusted hazard ratio (aHR) = 3.00; 95% CI: 1.22-7.37) as compared to those with early presentation for HIV/AIDS care. Adolescents within the age range of 15-19 years old (aHR = 3.56; 95% CI: 1.44-8.77), rural residence (aHR = 2.81; 95% CI: 1.39-5.68), poor adherence to ART (aHR = 3.17; 95% CI: 1.49-6.76), and being anemic (aHR = 3.09; 95% CI: 1.52-6.29) were other independent predictors of HIV-related mortality.
Conclusion: The study found a substantial link between HIV late presentation to care and mortality among adolescents. Residence, age, antiretroviral therapy (ART) medication adherence, and anemia status were also found to be other independent predictors of HIV-related mortality. To achieve the ultimate aim of lowering mortality among adolescents living with HIV, rigorous emphasis must be placed on early presentation for HIV/AIDS care. In addition, counseling on adherence and prompt diagnosis and treatment of anemia are highly recommended to reduce mortality.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Adolescence; Ethiopia; HIV-related mortality; Late presentation
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11209987
DOI: 10.1186/s12879-024-09550-3
PMID: 38926656
قاعدة البيانات: MEDLINE
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