دورية أكاديمية
أعرض في EDS

Prevalence, characteristics, and risk factors of non-alcoholic fatty liver disease in North East of Iran: a population-based study.

التفاصيل البيبلوغرافية
العنوان: Prevalence, characteristics, and risk factors of non-alcoholic fatty liver disease in North East of Iran: a population-based study.
المؤلفون: AkbariRad M; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Pezeshki Rad M; Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Nobakht H; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Moodi Ghalibaf A; Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran., Firoozi A; Mashhad University of Medical Sciences, Mashhad, Iran., Torshizian A; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Bina AR; Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran., Beheshti Namdar A; Department of Gastroenterology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. BeheshtiA@mums.ac.ir., Sadeghi M; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. sadeghi.masoume@gmail.com.; Department of Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. sadeghi.masoume@gmail.com.
المصدر: BMC gastroenterology [BMC Gastroenterol] 2024 Jun 26; Vol. 24 (1), pp. 212. Date of Electronic Publication: 2024 Jun 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Non-alcoholic Fatty Liver Disease*/epidemiology , Non-alcoholic Fatty Liver Disease*/diagnostic imaging, Humans ; Iran/epidemiology ; Male ; Female ; Prevalence ; Cross-Sectional Studies ; Risk Factors ; Middle Aged ; Adult ; Body Mass Index ; Ultrasonography ; Hypertension/epidemiology
مستخلص: Background: Nonalcoholic fatty liver disease (NAFLD) is a common dietary disorder caused by fatty changes in the liver parenchyma and hepatocytes without alcohol consumption. The present study aimed to investigate the prevalence, characteristics, and risk factors of NAFLD in the Mashhad Persian Cohort Study population.
Method: The present population-based cross-sectional study included all PERSIAN Organizational Cohort study in Mashhad University of Medical Sciences (POCM), Mashhad, Iran by census sampling method. Eligible participants were divided into two groups due to their NAFLD condition (NAFLD positive or NAFLD negative). All enrolled participants were evaluated based on their clinical aspects, anthropometric measures, laboratory tests, and ultrasound features. Statistical analysis was conducted using SPSS software version 16 (SPSS Inc., Chicago, USA -version 16). A P-value less than 0.05 was considered as the significance level.
Results: A total of 1198 individuals were included in the study, of which 638 (53.3%) were male and the rest were female. The mean age of the participants was 46.89 ± 8.98 years. A total of 246 patients (20.53%) were NAFLD positive, of which 122 (49.59%) were in grade 1, 112 (45.52%) were in grade 2, and 12 (4.87%) were in grade 3. The prevalence of fatty liver was significantly higher in males than in females (p < 0.001). There were significant differences between NAFLD positive and NAFLD negative participants in terms of having a history of hypertension (P = 0.044), body mass index (P < 0.001), body fat percentage (P = 0.001), waist circumference (P < 0.001), liver craniocaudal length (P = 0.012), fasting blood sugar (FBS) (P = 0.047), aspartate aminotransferase (AST) (P = 0.007), and alanine aminotransferase (ALT) (P = 0.001). Further analysis revealed a strong significant association between BMI, previous history of hypertension, higher levels of serum ALT, and NAFLD (P < 0.05).
Conclusion: It can be concluded that ultrasound findings accompanied by laboratory AST and ALT level enzymes could be a cost-benefit approach for NAFLD early diagnosis. The craniocaudal size of the liver could be a beneficent marker for estimating the severity of the disease; however, more studies are recommended to evaluate this variable for future practice against the issue.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Epidemiology; Liver disease; NAFLD; Non-alcoholic fatty liver disease; Risk factors
تواريخ الأحداث: Date Created: 20240626 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11210030
DOI: 10.1186/s12876-024-03302-y
PMID: 38926664
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-230X
DOI:10.1186/s12876-024-03302-y