دورية أكاديمية
أعرض في EDS

Comparing DAPSA, DAPSA28, and DAS28-CRP in Patients With Psoriatic Arthritis Initiating a First Tumor Necrosis Factor Inhibitor Across Nine European Countries.

التفاصيل البيبلوغرافية
العنوان: Comparing DAPSA, DAPSA28, and DAS28-CRP in Patients With Psoriatic Arthritis Initiating a First Tumor Necrosis Factor Inhibitor Across Nine European Countries.
المؤلفون: Linde L; Rigshospitalet, Glostrup, Denmark., Georgiadis S; Rigshospitalet, Glostrup, Denmark., Ørnbjerg LM; Rigshospitalet, Glostrup, Denmark., Rasmussen SH; Rigshospitalet, Glostrup, Denmark., Michelsen B; Rigshospitalet, Glostrup, Denmark, Diakonhjemmet Hospital, Oslo, Norway, and Sørlandet Sykehus HF, Kristiansand, Norway., Askling J; Karolinksa Institutet, Stockholm, Sweden., Di Giuseppe D; Karolinksa Institutet, Stockholm, Sweden., Wallman JK; Skåne University Hospital, Lund, Sweden., Závada J; Institute of Rheumatology and Charles University First Faculty of Medicine, Prague, the Czech Republic., Pavelka K; Institute of Rheumatology and Charles University First Faculty of Medicine, Prague, the Czech Republic., Bernardes M; University of Porto and Centro Hospitalar Universitário de São João, Porto, Portugal., Matos CO; Hospital de Santa Maria and Centro Academico de Medicina de Lisboa, Lisbon, Portugal., Glintborg B; The DANBIO Registry, Glostrup, Denmark, and University of Copenhagen, Copenhagen, Denmark., Loft AG; Aarhus University Hospital and Aarhus Universitet, Aarhus, Denmark., Nordström D; Helsinki University Central Hospital, Helsinki, Finland., Kuusalo L; University of Turku and Turku University Hospital, Turku, Finland., Möller B; Inselspital University Hospital Bern, Bern, Switzerland., Nissen MJ; Geneva University Hospitals, Geneva, Switzerland., Codreanu C; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Mogosan C; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Gudbjornsson B; Landspitali National University Hospital of Iceland and University of Iceland, Reykjavik, Iceland., Love TJ; Landspitali National University Hospital of Iceland and University of Iceland, Reykjavik, Iceland., Akleylek C; TC Demiroglu Bilim University, Istanbul, Turkey., Iannone F; University of Bari, Bari, Italy., Kvien TK; Diakonhjemmet Hospital, Oslo, Norway., Rotar Z; University Medical Centre Ljubljana and University of Ljubljana, Ljubljana, Slovenia., Castrejon I; General University Hospital Gregorio Maranon and Complutense University of Madrid, Madrid, Spain., Macfarlane GJ; University of Aberdeen, Aberdeen, Scotland., Hetland ML; Rigshospitalet, Glostrup, Denmark, and University of Copenhagen, Copenhagen, Denmark., Østergaard M; Rigshospitalet, Glostrup, Denmark, and University of Copenhagen, Copenhagen, Denmark.
المصدر: Arthritis care & research [Arthritis Care Res (Hoboken)] 2024 Jun 26. Date of Electronic Publication: 2024 Jun 26.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : John Wiley & Sons
مستخلص: Objective: Because 66/68 joint counts are not always performed in routine care, we aimed to determine which of the modified 28-joint disease activity index for psoriatic arthritis (DAPSA28) or 28-joint disease activity score with C-reactive protein (DAS28-CRP) should be preferred for monitoring disease activity in psoriatic arthritis (PsA) when the original DAPSA (66/68 joints) is not available.
Methods: Prospectively collected real-world data of European bionaive patients with PsA initiating a first tumor necrosis factor inhibitor were pooled. Remission and response status were evaluated at 6 months by remission (DAPSA ≤ 4, DAPSA28 ≤ 4, and DAS28-CRP < 2.6), response (75% improvement for DAPSA and DAPSA28), and combined EULAR good/moderate responses for DAS28-CRP. Logistic regression analyses on multiple imputed data were used to identify baseline predictors.
Results: Remission and response cohorts included 3,159 and 1,866 patients, respectively. The 6-month proportions achieving remission/response were DAPSA (27%/44%), DAPSA28 (28%/44%), and DAS28-CRP (59%/80%). Of 14 possible baseline predictors, 11 predicted both DAPSA and DAPSA28 remission (8 of which also predicted their response, indicated by "*"): longer disease duration*, male sex*, and higher CRP* were positive, whereas older age*, higher body mass index*, patient fatigue*, and global, physician global, health assessment questionnaire score*, and tender and swollen* joint counts were negative predictors. Eight and five of these predicted DAS28-CRP remission and response, respectively.
Conclusion: In patients with PsA, DAPSA28 should be preferred over DAS28-CRP as a substitute for DAPSA when 66/68 joint counts are not available because of the large overlap in remission and response status and in predictors between DAPSA and DAPSA28.
(© 2024 The Author(s). Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
References: Schoels MM, Aletaha D, Alasti F, et al. Disease activity in psoriatic arthritis (PsA): defining remission and treatment success using the DAPSA score. Ann Rheum Dis 2016;75(5):811–818.
Duarte‐García A, Leung YY, Coates LC, et al. Endorsement of the 66/68 joint count for the measurement of musculoskeletal disease activity: OMERACT 2018 Psoriatic Arthritis Workshop Report. J Rheumatol 2019;46(8):996–1005.
Michelsen B, Sexton J, Smolen JS, et al. Can disease activity in patients with psoriatic arthritis be adequately assessed by a modified disease activity index for PSoriatic Arthritis (DAPSA) based on 28 joints? Ann Rheum Dis 2018;77(12):1736–1741.
Nash P, Behrens F, Orbai AM, et al. Ixekizumab is efficacious when used alone or when added to conventional synthetic disease‐modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inhibitors. RMD Open 2018;4(2):e000692.
Prevoo MLL, van ‘t Hof MA, Kuper HH, et al. Modified disease activity scores that include twenty‐eight‐joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38(1):44–48.
Gladman DD, Antoni C, Mease P, et al. Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis 2005;64(Suppl 2)(suppl 2):ii14–ii17.
Orbai AM, de Wit M, Mease PJ, et al. Updating the psoriatic arthritis (PsA) core domain set: a report from the PsA Workshop at OMERACT 2016. J Rheumatol 2017;44(10):1522–1528.
Michelsen B, Georgiadis S, Di Giuseppe D, et al. Real‐world six‐ and twelve‐month drug retention, remission, and response rates of secukinumab in 2,017 patients with psoriatic arthritis in thirteen European countries. Arthritis Care Res (Hoboken) 2022;74(7):1205–1218.
Lindqvist U, Wernroth ML, Husmark T, et al; The Swedish Early Psoriatic Arthritis Cohort. DAPSA, DAS28 and MDA predict long‐term treatment regime in psoriatic arthritis. Clin Exp Rheumatol 2017;35(6):936–942.
Khraishi MM, Remple VP, Silverberg S, et al. Canadian adalimumab postmarketing observational epidemiological study assessing effectiveness in psoriatic arthritis (COMPLETE‐PsA): 12‐month results of comparative effectiveness of adalimumab and nbDMARDs. J Rheumatol 2022;49(5):454–464.
Karadag O, Dalkilic E, Ayan G, et al. Real‐world data on change in work productivity, activity impairment, and quality of life in patients with psoriatic arthritis under anti‐TNF therapy: a postmarketing, noninterventional, observational study. Clin Rheumatol 2022;41(1):85–94.
Brahe CH, Ørnbjerg LM, Jacobsson L, et al. Retention and response rates in 14 261 PsA patients starting TNF inhibitor treatment‐results from 12 countries in EuroSpA. Rheumatology (Oxford) 2020;59(7):1640–1650.
Palsson O, Love TJ, Gunnarsdottir AI, et al. Patients with psoriatic arthritis who are not eligible for randomised controlled trials for TNF inhibitors have treatment response and drug survival similar to those who are eligible. RMD Open 2019;5(2):e000984.
Linde L, Ørnbjerg LM, Rasmussen SH, et al. Commonalities and differences in set‐up and data collection across European spondyloarthritis registries — results from the EuroSpA collaboration. Arthritis Res Ther 2023;25:205.
van Riel PLCM, van Gestel AM, van de Putte LBA. Development and validation of response criteria in rheumatoid arthritis: steps towards an international consensus on prognostic markers. Br J Rheumatol 1996;35(suppl 2):4–7.
National Accounts Section. Basic data selection. United Nations Statistics Division. Accessed July 7th 2023. https://unstats.un.org/unsd/snaama/Basic.
Wood AM, White IR, Royston P. How should variable selection be performed with multiply imputed data? Stat Med 2008;27(17):3227–3246.
Wahl S, Boulesteix AL, Zierer A, et al. Assessment of predictive performance in incomplete data by combining internal validation and multiple imputation. BMC Med Res Methodol 2016;16(1):144.
Linde L, Ørnbjerg LM, Georgiadis S, et al. Predictors of DAPSA28 remission in patients with psoriatic arthritis initiating a first TNF inhibitor: results from 13 European registries. Rheumatology (Oxford) 2024;63(3):751–764.
Scrivo R, Giardino AM, Salvarani C, et al; Predicting MDA in PsA Study Group. An observational prospective study on predictors of clinical response at six months in patients with active psoriatic arthritis treated with golimumab. Clin Exp Rheumatol 2020;38(1):107–114.
Van den Bosch F, Manger B, Goupille P, et al. Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions. Ann Rheum Dis 2010;69(2):394–399.
معلومات مُعتمدة: Novartis Pharma AG and IQVIA
تواريخ الأحداث: Date Created: 20240626 Latest Revision: 20240820
رمز التحديث: 20240820
DOI: 10.1002/acr.25396
PMID: 38926900
قاعدة البيانات: MEDLINE
الوصف
تدمد:2151-4658
DOI:10.1002/acr.25396