دورية أكاديمية
أعرض في EDS

Evaluation of the Canonical Wnt Signaling Pathway in the Hearts of Hypertensive Rats of Various Etiologies.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the Canonical Wnt Signaling Pathway in the Hearts of Hypertensive Rats of Various Etiologies.
المؤلفون: Młynarczyk MA; Department of Histology and Cytophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland., Domian N; Department of Histology and Cytophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland., Kasacka I; Department of Histology and Cytophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 11; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Wnt Signaling Pathway* , Hypertension*/metabolism , Hypertension*/etiology , Hypertension*/chemically induced , Hypertension*/pathology , Glycogen Synthase Kinase 3 beta*/metabolism , Myocardium*/metabolism , Myocardium*/pathology , beta Catenin*/metabolism , beta Catenin*/genetics, Animals ; Rats ; Male ; Wnt1 Protein/metabolism ; Wnt1 Protein/genetics ; Rats, Inbred SHR ; Frizzled Receptors/metabolism ; Frizzled Receptors/genetics ; Desoxycorticosterone Acetate
مستخلص: Wnt/β-catenin signaling dysregulation is associated with the pathogenesis of many human diseases, including hypertension and heart disease. The aim of this study was to immunohistochemically evaluate and compare the expression of the Fzd8, WNT1, GSK-3β, and β-catenin genes in the hearts of rats with spontaneous hypertension (SHRs) and deoxycorticosterone acetate (DOCA)-salt-induced hypertension. The myocardial expression of Fzd8, WNT1, GSK-3β, and β-catenin was detected by immunohistochemistry, and the gene expression was assessed with a real-time PCR method. In SHRs, the immunoreactivity of Fzd8, WNT1, GSK-3β, and β-catenin was attenuated in comparison to that in normotensive animals. In DOCA-salt-induced hypertension, the immunoreactivity of Fzd8, WNT1, GSK-3β, and β-catenin was enhanced. In SHRs, decreases in the expression of the genes encoding Fzd8, WNT1, GSK-3β, and β-catenin were observed compared to the control group. Increased expression of the genes encoding Fzd8, WNT1, GSK-3β, and β-catenin was demonstrated in the hearts of rats with DOCA-salt-induced hypertension. Wnt signaling may play an essential role in the pathogenesis of arterial hypertension and the accompanying heart damage. The obtained results may constitute the basis for further research aimed at better understanding the role of the Wnt/β-catenin pathway in the functioning of the heart.
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فهرسة مساهمة: Keywords: Wnt/β-catenin; arterial hypertension; essential hypertension; myocardium; secondary hypertension
المشرفين على المادة: EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
0 (beta Catenin)
0 (Wnt1 Protein)
0 (Frizzled Receptors)
6E0A168OB8 (Desoxycorticosterone Acetate)
0 (Wnt1 protein, rat)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11204257
DOI: 10.3390/ijms25126428
PMID: 38928134
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25126428