دورية أكاديمية
أعرض في EDS

Updates on C3 Glomerulopathy in Kidney Transplantation: Pathogenesis and Treatment Options.

التفاصيل البيبلوغرافية
العنوان: Updates on C3 Glomerulopathy in Kidney Transplantation: Pathogenesis and Treatment Options.
المؤلفون: Bartoli G; Department of Translational Medicine and Surgery, Università Cattolica dl Sacro Cuore, 00168 Rome, Italy., Dello Strologo A; Department of Translational Medicine and Surgery, Università Cattolica dl Sacro Cuore, 00168 Rome, Italy., Grandaliano G; Department of Translational Medicine and Surgery, Università Cattolica dl Sacro Cuore, 00168 Rome, Italy.; Nephrology, Dialysis and Transplantation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy., Pesce F; Department of Translational Medicine and Surgery, Università Cattolica dl Sacro Cuore, 00168 Rome, Italy.; Division of Renal Medicine, 'Ospedale Isola Tiberina-Gemelli Isola', 00186 Rome, Italy.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 13; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 13.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects , Complement C3*/metabolism, Humans ; Graft Rejection/etiology ; Glomerulonephritis/etiology ; Glomerulonephritis/drug therapy ; Glomerulonephritis/therapy ; Mycophenolic Acid/therapeutic use
مستخلص: C3 glomerulopathy is a rare disease, characterized by an abnormal activation of the complement's alternative pathway that leads to the accumulation of the C3 component in the kidney. The disease recurs in more than half of kidney transplant recipients, with a significant impact on graft survival. Recurrence of the primary disease represents the second cause of graft loss after organ rejection. In C3 glomerulopathy, there are several risk factors which can promote a recurrence during transplantation, such as delayed graft function, infection and monoclonal gammopathy. All these events can trigger the alternative complement pathway. In this review, we summarize the impact of C3 glomerulopathy on kidney grafts and present the latest treatment options. The most widely used treatments for the disease include corticosteroids and mycophenolate mofetil, which are already used chronically by kidney transplant recipients; thus, additional treatments for C3 glomerulopathy are required. Currently, several studies using anti-complement drugs (i.e., eculizumab, Ravalizumab, avacopan) for C3 glomerulopathy in kidney transplant patients are ongoing with encouraging results.
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فهرسة مساهمة: Keywords: C3 glomerulopathy; infection; kidney transplantation; monoclonal gammopathy; treatment
المشرفين على المادة: 0 (Complement C3)
HU9DX48N0T (Mycophenolic Acid)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240717
رمز التحديث: 20240717
مُعرف محوري في PubMed: PMC11204074
DOI: 10.3390/ijms25126508
PMID: 38928213
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25126508