دورية أكاديمية
أعرض في EDS

Supercritical Carbon Dioxide Extraction of Coumarins from the Aerial Parts of Pterocaulon polystachyum .

التفاصيل البيبلوغرافية
العنوان: Supercritical Carbon Dioxide Extraction of Coumarins from the Aerial Parts of Pterocaulon polystachyum .
المؤلفون: Scopel JM; Unit Operations Laboratory (LOPE), School of Technology, Pontifical Catholic University of Rio Grande do Sul, Av Ipiranga 6681, Building 30, Block F, Room 208, Porto Alegre 90619-900, RS, Brazil., Medeiros-Neves B; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Teixeira HF; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Brazil NT; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Bordignon SAL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Diz FM; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre 90619-900, RS, Brazil., Morrone FB; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre 90619-900, RS, Brazil., Almeida RN; Unit Operations Laboratory (LOPE), School of Technology, Pontifical Catholic University of Rio Grande do Sul, Av Ipiranga 6681, Building 30, Block F, Room 208, Porto Alegre 90619-900, RS, Brazil., Cassel E; Unit Operations Laboratory (LOPE), School of Technology, Pontifical Catholic University of Rio Grande do Sul, Av Ipiranga 6681, Building 30, Block F, Room 208, Porto Alegre 90619-900, RS, Brazil., von Poser GL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre 90010-150, RS, Brazil., Vargas RMF; Unit Operations Laboratory (LOPE), School of Technology, Pontifical Catholic University of Rio Grande do Sul, Av Ipiranga 6681, Building 30, Block F, Room 208, Porto Alegre 90619-900, RS, Brazil.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 08; Vol. 29 (12). Date of Electronic Publication: 2024 Jun 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Coumarins*/chemistry , Coumarins*/isolation & purification , Coumarins*/pharmacology , Carbon Dioxide*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Chromatography, Supercritical Fluid*/methods, Humans ; Plant Components, Aerial/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification
مستخلص: Pterocaulon polystachyum is a species of pharmacological interest for providing volatile and non-volatile extracts with antifungal and amebicidal properties. The biological activities of non-volatile extracts may be related to the presence of coumarins, a promising group of secondary metabolites. In the present study, leaves and inflorescences previously used for the extraction of essential oils instead of being disposed of were subjected to extraction with supercritical CO 2 after pretreatment with microwaves. An experimental design was followed to seek the best extraction condition with the objective function being the maximum total extract. Pressure and temperature were statistically significant factors, and the optimal extraction condition was 240 bar, 60 °C, and pretreatment at 30 °C. The applied mathematical models showed good adherence to the experimental data. The extracts obtained by supercritical CO 2 were analyzed and the presence of coumarins was confirmed. The extract investigated for cytotoxicity against bladder tumor cells (T24) exhibited significant reduction in cell viability at concentrations between 6 and 12 μg/mL. The introduction of green technology, supercritical extraction, in the exploration of P. polystachyum as a source of coumarins represents a paradigm shift with regard to previous studies carried out with this species, which used organic solvents. Furthermore, the concept of circular bioeconomy was applied, i.e., the raw material used was the residue of a steam-distillation process. Therefore, the approach used here is in line with the sustainable exploitation of native plants to obtain extracts rich in coumarins with cytotoxic potential against cancer cells.
References: Molecules. 2017 Jul 14;22(7):. (PMID: 28708073)
Planta Med. 2001 Oct;67(7):674-7. (PMID: 11582550)
Planta Med. 1999 Apr;65(3):294-5. (PMID: 17260310)
J Biol Chem. 2020 Apr 10;295(15):5022-5035. (PMID: 32005659)
J Ethnopharmacol. 2000 Jul;71(1-2):145-51. (PMID: 10904157)
J Ethnopharmacol. 2018 Oct 5;224:451-464. (PMID: 29913300)
Eur J Med Chem. 2012 Nov;57:268-74. (PMID: 23069682)
Cancer Lett. 2004 Jul 16;210(2):179-88. (PMID: 15183533)
Carbohydr Polym. 2013 Jun 5;95(1):588-97. (PMID: 23618310)
Molecules. 2017 Feb 24;22(3):. (PMID: 28245577)
J Agric Food Chem. 2013 May 22;61(20):4667-75. (PMID: 23634989)
Curr Opin Biotechnol. 2007 Dec;18(6):497-503. (PMID: 17988854)
J Chromatogr A. 2012 Aug 10;1250:34-48. (PMID: 22595519)
J Environ Sci (China). 2009;21(6):720-6. (PMID: 19803072)
فهرسة مساهمة: Keywords: Pterocaulon polystachyum; cell viability assay; coumarin; mathematical modeling; supercritical fluid extraction
المشرفين على المادة: 0 (Coumarins)
142M471B3J (Carbon Dioxide)
0 (Plant Extracts)
0 (Antineoplastic Agents, Phytogenic)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11205997
DOI: 10.3390/molecules29122741
PMID: 38930806
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29122741