دورية أكاديمية
أعرض في EDS

Vitamin K for Vascular Calcification in Kidney Patients: Still Alive and Kicking, but Still a Lot to Learn.

التفاصيل البيبلوغرافية
العنوان: Vitamin K for Vascular Calcification in Kidney Patients: Still Alive and Kicking, but Still a Lot to Learn.
المؤلفون: Neofytou IE; 2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece., Stamou A; 2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece., Demopoulos A; 2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece., Roumeliotis S; 2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece., Zebekakis P; 1st Department of Internal Medicine, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece., Liakopoulos V; 2nd Department of Nephrology, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece., Stamellou E; Department of Nephrology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.; Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52062 Aachen, Germany., Dounousi E; Department of Nephrology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
المصدر: Nutrients [Nutrients] 2024 Jun 07; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 07.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Vascular Calcification*/etiology , Vitamin K* , Renal Insufficiency, Chronic*/complications , Matrix Gla Protein* , Vitamin K Deficiency*/complications , Extracellular Matrix Proteins*/blood , Extracellular Matrix Proteins*/metabolism, Humans ; Calcium-Binding Proteins/blood ; Dietary Supplements ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Biomarkers/blood
مستخلص: Patients with chronic kidney disease (CKD) suffer disproportionately from a high burden of cardiovascular disease, which, despite recent scientific advances, remains partly understood. Vascular calcification (VC) is the result of an ongoing process of misplaced calcium in the inner and medial layers of the arteries, which has emerged as a critical contributor to cardiovascular events in CKD. Beyond its established role in blood clotting and bone health, vitamin K appears crucial in regulating VC via vitamin K-dependent proteins (VKDPs). Among these, the matrix Gla protein (MGP) serves as both a potent inhibitor of VC and a valuable biomarker (in its inactive form) for reflecting circulating vitamin K levels. CKD patients, especially in advanced stages, often present with vitamin K deficiency due to dietary restrictions, medications, and impaired intestinal absorption in the uremic environment. Epidemiological studies confirm a strong association between vitamin K levels, inactive MGP, and increased CVD risk across CKD stages. Based on the promising results of pre-clinical data, an increasing number of clinical trials have investigated the potential benefits of vitamin K supplementation to prevent, delay, or even reverse VC, but the results have remained inconsistent.
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فهرسة مساهمة: Keywords: CKD; PIVKA-II; dp-ucMGP; menaquinone-7; vascular calcification; vitamin K
المشرفين على المادة: 12001-79-5 (Vitamin K)
0 (Matrix Gla Protein)
0 (Extracellular Matrix Proteins)
0 (Calcium-Binding Proteins)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11206649
DOI: 10.3390/nu16121798
PMID: 38931153
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16121798