دورية أكاديمية
Noninvasive Temperature Measurements in Tissue-Simulating Phantoms Using a Solid-State Near-Infrared Sensor.
| العنوان: | Noninvasive Temperature Measurements in Tissue-Simulating Phantoms Using a Solid-State Near-Infrared Sensor. |
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| المؤلفون: | Kauffman A; Rockley Photonics Inc., Irvine, CA 92614, USA., Nguyen JQ; Rockley Photonics Inc., Irvine, CA 92614, USA., Parthasarathy S; Rockley Photonics Inc., Irvine, CA 92614, USA., Arnold MA; Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA. |
| المصدر: | Sensors (Basel, Switzerland) [Sensors (Basel)] 2024 Jun 19; Vol. 24 (12). Date of Electronic Publication: 2024 Jun 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101204366 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-8220 (Electronic) Linking ISSN: 14248220 NLM ISO Abbreviation: Sensors (Basel) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c2000- |
| مواضيع طبية MeSH: | Phantoms, Imaging* , Spectroscopy, Near-Infrared*/methods , Spectroscopy, Near-Infrared*/instrumentation, Humans ; Least-Squares Analysis ; Calibration ; Skin/chemistry ; Gelatin/chemistry ; Temperature ; Water/chemistry ; Wearable Electronic Devices ; Emulsions/chemistry ; Soybean Oil/chemistry ; Phospholipids |
| مستخلص: | The monitoring of body temperature is a recent addition to the plethora of parameters provided by wellness and fitness wearable devices. Current wearable temperature measurements are made at the skin surface, a measurement that is impacted by the ambient environment of the individual. The use of near-infrared spectroscopy provides the potential for a measurement below the epidermal layer of skin, thereby having the potential advantage of being more reflective of physiological conditions. The feasibility of noninvasive temperature measurements is demonstrated by using an in vitro model designed to mimic the near-infrared spectra of skin. A miniaturizable solid-state laser-diode-based near-infrared spectrometer was used to collect diffuse reflectance spectra for a set of seven tissue phantoms composed of different amounts of water, gelatin, and Intralipid. Temperatures were varied between 20-24 °C while collecting these spectra. Two types of partial least squares (PLS) calibration models were developed to evaluate the analytical utility of this approach. In both cases, the collected spectra were used without pre-processing and the number of latent variables was the only optimized parameter. The first approach involved splitting the whole dataset into separate calibration and prediction subsets for which a single optimized PLS model was developed. For this first case, the coefficient of determination (R 2 ) is 0.95 and the standard error of prediction (SEP) is 0.22 °C for temperature predictions. The second strategy used a leave-one-phantom-out methodology that resulted in seven PLS models, each predicting the temperatures for all spectra in the held-out phantom. For this set of phantom-specific predicted temperatures, R 2 and SEP values range from 0.67-0.99 and 0.19-0.65 °C, respectively. The stability and reproducibility of the sample-to-spectrometer interface are identified as major sources of spectral variance within and between phantoms. Overall, results from this in vitro study justify the development of future in vivo measurement technologies for applications as wearables for continuous, real-time monitoring of body temperature for both healthy and ill individuals. |
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| فهرسة مساهمة: | Keywords: body temperature sensing; near-infrared spectroscopy; silicon photonic integrated chip; temperature; tissue phantoms; wearable technologies |
| المشرفين على المادة: | 9000-70-8 (Gelatin) 059QF0KO0R (Water) 0 (Emulsions) 0 (soybean oil, phospholipid emulsion) 8001-22-7 (Soybean Oil) 0 (Phospholipids) |
| تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629 |
| رمز التحديث: | 20240629 |
| مُعرف محوري في PubMed: | PMC11207550 |
| DOI: | 10.3390/s24123985 |
| PMID: | 38931768 |
| قاعدة البيانات: | MEDLINE |
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