دورية أكاديمية
Ethylene Oxide Hemoglobin Adducts in Cord Blood and Offspring's Size at Birth: The NewGeneris European Cohort Study.
| العنوان: | Ethylene Oxide Hemoglobin Adducts in Cord Blood and Offspring's Size at Birth: The NewGeneris European Cohort Study. |
|---|---|
| المؤلفون: | Harding BN; From the Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBERESP, Madrid, Spain., Agramunt S; Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain., Pedersen M; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Knudsen LE; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Nielsen JKS; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Wright J; Bradford Institute for Heath Research, Bradford, United Kingdom., Vafeiadi M; Department of Social Medicine, School of Medicine, University of Crete, Heraklion, Crete, Greece., Merlo DF; Scientific Department, Azienda USL-IRCCS reggio Emilia, Reggio Emilia, Italy., Stayner L; Division of Epidemiology and Biostatistics, UIC School of Public Health, Chicago, IL., Kelly-Reif K; National Institute for Occupational Health and Safety, Division of Field Studies and Engineering, Cincinnati, OH., Espinosa A; From the Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBERESP, Madrid, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Bustamante M; From the Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBERESP, Madrid, Spain., Gützkow KB; Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Granum B; Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., von Stedingk H; Stockholm University, Stockholm, Sweden., Rydberg P; Department of Oncology-Pathology, Karolinska Institute, Solna, Sweden., Alexander J; Norwegian Institute of Public Health, Oslo, Norway., Törnqvist M; Stockholm University, Stockholm, Sweden., Kogevinas M; From the Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBERESP, Madrid, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain. |
| المصدر: | Epidemiology (Cambridge, Mass.) [Epidemiology] 2024 Sep 01; Vol. 35 (5), pp. 710-720. Date of Electronic Publication: 2024 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9009644 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-5487 (Electronic) Linking ISSN: 10443983 NLM ISO Abbreviation: Epidemiology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000>- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [Cambridge, MA : Blackwell Scientific Publications ; Chestnut Hill, MA : Epidemiology Resources, c1990- |
| مواضيع طبية MeSH: | Fetal Blood*/chemistry , Birth Weight*/drug effects , Cytochrome P-450 CYP2E1*/genetics , Hemoglobins*/analysis , Ethylene Oxide*, Humans ; Female ; Infant, Newborn ; Pregnancy ; Prospective Studies ; Male ; Europe ; Adult ; Polymorphism, Single Nucleotide ; Maternal Exposure/adverse effects ; Prenatal Exposure Delayed Effects ; Linear Models ; Infant, Small for Gestational Age ; Cohort Studies |
| مستخلص: | Background: Prenatal ethylene oxide exposure may have adverse effects on fetal development. We examined the relationships between ethylene oxide hemoglobin (Hb) adduct levels and offspring's size at birth in a prospective European mother-child study. Methods: This study included 1106 singletons from the NewGeneris project (2006-2010) with ethylene oxide Hb adducts measured in cord blood. We examined the relationships between adduct levels and offspring's size at birth among all infants and separately among infants of nonsmokers, using linear regression models for birth weight and birth head circumference and logarithmic binomial regression models for small for gestational age. We examined potential interactions between CYP2E1 single nucleotide polymorphisms in cord blood and the effects of ethylene oxide Hb adduct levels on offspring birth size. Results: Higher quartiles of adduct levels as a measure of exposure were associated with decreasing birth weight and head circumference in the overall population. Compared to infants in the lowest quartile, those in the highest quartile exhibited lower birth weight (-70.73 g, 95% confidence interval = -141.16, -0.30) and reduced head circumference (-0.30 cm, 95% confidence interval = -0.58, -0.02). We observed similar, albeit less pronounced, patterns among infants of nonsmokers. There was no evidence of an association between ethylene oxide Hb adducts and risk of small for gestational age, nor consistent evidence of an interaction with CYP2E1 polymorphisms on the association between EO Hb adduct levels and offspring's size at birth. Conclusion: Results suggest that higher ethylene oxide Hb adduct levels in cord blood are associated with a reduction in offspring birth size. Competing Interests: Disclosure: The authors report no conflicts of interest. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| References: | Tates AD, Grummt T, Tornqvist M, et al. Biological and chemical monitoring of occupational exposure to ethylene oxide. Mutat Res. 1991;250:483–497. van Sittert NJ, Boogaard PJ, Natarajan AT, Tates AD, Ehrenberg LG, Tornqvist MA. Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment. Mutat Res. 2000;447:27–48. IARC. Chemical agents and related occupations. In: IARC Monographs. 2012:100F. Steenland K, Stayner L, Deddens J. Mortality analyses in a cohort of 18 235 ethylene oxide exposed workers: follow up extended from 1987 to 1998. Occup Environ Med. 2004;61:2–7. Steenland K, Whelan E, Deddens J, Stayner L, Ward E. Ethylene oxide and breast cancer incidence in a cohort study of 7576 women (United States). Cancer Causes Control. 2003;14:531–539. National Toxicology Program. Ethylene oxide: CAS No. 75-21-8. In: 15th Report on Carcinogens. 2021. Available at: https://www.ncbi.nlm.nih.gov/books/NBK590871/ . Accessed 23 October 2023. Hemminki K, Mutanen P, Saloniemi I, Niemi ML, Vainio H. Spontaneous abortions in hospital staff engaged in sterilising instruments with chemical agents. Br Med J (Clin Res Ed). 1982;285:1461–1463. Gresie-Brusin DF, Kielkowski D, Baker A, Channa K, Rees D. Occupational exposure to ethylene oxide during pregnancy and association with adverse reproductive outcomes. Int Arch Occup Environ Health. 2007;80:559–565. Agency for Toxic Substances and Disease Registry (US). Chapter 2, Health effects. In: Toxicological Profile for Ethylene Oxide. 2022. Available at: https://www.ncbi.nlm.nih.gov/books/NBK589511/ . Accessed 23 October 2023. Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder. Chem Res Toxicol. 2001;14:767–790. Persson KA, Berg S, Tornqvist M, Scalia-Tomba GP, Ehrenberg L. Note on ethene and other low-molecular weight hydrocarbons in environmental tobacco smoke. Acta Chem Scand B. 1988;42:690–696. Jones RR, Fisher JA, Medgyesi DN, et al. Ethylene oxide emissions and incident breast cancer and non-Hodgkin lymphoma in a US cohort. J Natl Cancer Inst. 2023;115:405–412. Galarneau E, Yacovitch TI, Lerner B, et al. From hotspots to background: high-resolution mapping of ethylene oxide in urban air. Atmos Environ. 2023;307:119828. Morgott DA. Anthropogenic and biogenic sources of ethylene and the potential for human exposure: a literature review. Chem Biol Interact. 2015;241:10–22. Chang C. Q&A: How do plants respond to ethylene and what is its importance? BMC Biol. 2016;14:7. Dudkiewicz A, Dutta P, Kołożyn-Krajewska D. Ethylene oxide in foods: current approach to the risk assessment and practical considerations based on the European food business operator perspective. Eur Food Res Technol. 2022;248:1951–1958. Swenberg JA, Lu K, Moeller BC, et al. Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment. Toxicol Sci. 2011;120:S130–S145. Filser JG, Denk B, Tornqvist M, Kessler W, Ehrenberg L. Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch Toxicol. 1992;66:157–163. Filser JG, Klein D. A physiologically based toxicokinetic model for inhaled ethylene and ethylene oxide in mouse, rat, and human. Toxicol Lett. 2018;286:54–79. Fennell TR, Snyder RW, Parkinson C, Murphy J, James RA. The effect of ethylene exposure on ethylene oxide in blood and on hepatic cytochrome p450 in Fischer rats. Toxicol Sci. 2004;81:7–13. Csanady GA, Denk B, Putz C, et al. A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse, and human: formation of 2-hydroxyethyl adducts with hemoglobin and DNA. Toxicol Appl Pharmacol. 2000;165:1–26. Haufroid V, Merz B, Hofmann A, Tschopp A, Lison D, Hotz P. Exposure to ethylene oxide in hospitals: biological monitoring and influence of glutathione S-transferase and epoxide hydrolase polymorphisms. Cancer Epidemiol Biomarkers Prev. 2007;16:796–802. Tornqvist M, Fred C, Haglund J, Helleberg H, Paulsson B, Rydberg P. Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;778:279–308. von Stedingk H., Osterman-Golkar S., Törnqvist M. Biomarkers of exposure: hemoglobin adducts. In: Knudsen LE, Merlo DF, eds. Biomarkers and Human Biomonitoring, Vol 2: Selected Biomarkers of Current Interest. The Royal Society of Chemistry; 2012:1–22. Center for Disease Control and Prevention. National Center for Environmental Health. National Report on Human Exposure to Environmental Chemicals. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. 2022. Updated March 2024. Available at: https://www.cdc.gov/environmental-exposure-report/about/suggested-citation.html . Accessed 10 November 2023. Tornqvist M. Is ambient ethene a cancer risk factor? Environ Health Perspect. 1994;102:157–160. Szwiec E, Friedman L, Buchanan S. Levels of ethylene oxide biomarker in an exposed residential community. Int J Environ Res Public Health. 2020;17:8646. von Stedingk H, Vikstrom AC, Rydberg P, et al. Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark. Chem Res Toxicol. 2011;24:1957–1965. Wild CP, Kleinjans J. Children and increased susceptibility to environmental carcinogens: evidence or empathy? Cancer Epidemiol Biomarkers Prev. 2003;12:1389–1394. Zhang HD, Ma YJ, Liu QF, et al. Human erythrocyte lifespan measured by Levitt’s CO breath test with newly developed automatic instrument. J Breath Res. 2018;12:036003. Dziegiel MH, Koldkjaer O, Berkowicz A. Massive antenatal fetomaternal hemorrhage: evidence for long-term survival of fetal red blood cells. Transfusion. 2005;45:539–544. Merlo DF, Wild CP, Kogevinas M, Kyrtopoulos S, Kleinjans J; NewGeneris Consortium. NewGeneris: a European study on maternal diet during pregnancy and child health. Cancer Epidemiol Biomarkers Prev. 2009;18:5–10. Oudgenoeg-Paz O, Mulder H, Jongmans MJ, van der Ham IJM, Van der Stigchel S. The link between motor and cognitive development in children born preterm and/or with low birth weight: a review of current evidence. Neurosci Biobehav Rev. 2017;80:382–393. Barker DJ, Osmond C, Simmonds SJ, Wield GA. The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. BMJ. 1993;306:422–426. Chen W, Srinivasan SR, Yao L, et al. Low birth weight is associated with higher blood pressure variability from childhood to young adulthood: the Bogalusa Heart Study. Am J Epidemiol. 2012;176:S99–105. Gale CR, O’Callaghan FJ, Bredow M, Martyn CN; Avon Longitudinal Study of Parents and Children Study Team. The influence of head growth in fetal life, infancy, and childhood on intelligence at the ages of 4 and 8 years. Pediatrics. 2006;118:1486–1492. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61–73. Magnus P, Birke C, Vejrup K, et al. Cohort profile update: the Norwegian mother and child cohort study (MoBa). Int J Epidemiol. 2016;45:382–388. Pedersen M, von Stedingk H, Botsivali M, et al.; NewGeneris Consortium. Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother–child study (NewGeneris). Environ Health Perspect. 2012;120:1739–1745. von Stedingk H, Rydberg P, Tornqvist M. A new modified Edman procedure for analysis of N-terminal valine adducts in hemoglobin by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:2483–2490. Rowland AS, Baird DD, Shore DL, Darden B, Wilcox AJ. Ethylene oxide exposure may increase the risk of spontaneous abortion, preterm birth, and postterm birth. Epidemiology. 1996;7:363–368. Lawson CC, Rocheleau CM, Whelan EA, et al. Occupational exposures among nurses and risk of spontaneous abortion. Am J Obstet Gynecol. 2012;206:327.e1–8. Preston RJ. Cytogenetic effects of ethylene oxide, with an emphasis on population monitoring. Crit Rev Toxicol. 1999;29:263–282. Steenland K, Stayner L, Greife A, et al. Mortality among workers exposed to ethylene oxide. N Engl J Med. 1991;324:1402–1407. Mattison DR. Environmental exposures and development. Curr Opin Pediatr. 2010;22:208–218. Ethylene Oxide (EtO): Evidence of Carcinogenicity. DHHS (NIOSH) PUBLICATION NUMBER 81-130. National Institute for Occupational Safety and Health. May 1981. Available at: https://www.cdc.gov/niosh/docs/81-130/default.html . Accessed 23 October 2023. Embree JW, Lyon JP, Hine CH. The mutagenic potential of ethylene oxide using the dominant--lethal assay in rats. Toxicol Appl Pharmacol. 1977;40:261–267. Kenwood BM, McLoughlin C, Zhang L, et al. Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Biomarkers. 2021;26:656–664. Wiebel FA, Dommermuth A, Thier R. The hereditary transmission of the glutathione transferase hGSTT1-1 conjugator phenotype in a large family. Pharmacogenetics. 1999;9:251–256. U.S. EPA. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Final Report). EPA/635/R-16/350F; 2016. |
| معلومات مُعتمدة: | N01ES75558 United States ES NIEHS NIH HHS; U01 NS047537 United States NS NINDS NIH HHS |
| المشرفين على المادة: | EC 1.14.13.- (Cytochrome P-450 CYP2E1) 0 (Hemoglobins) JJH7GNN18P (Ethylene Oxide) |
| تواريخ الأحداث: | Date Created: 20240627 Date Completed: 20240807 Latest Revision: 20240830 |
| رمز التحديث: | 20240830 |
| مُعرف محوري في PubMed: | PMC11309333 |
| DOI: | 10.1097/EDE.0000000000001767 |
| PMID: | 38935439 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-5487 |
|---|---|
| DOI: | 10.1097/EDE.0000000000001767 |