دورية أكاديمية
أعرض في EDS

Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus, Denmark, 2020-2023.

التفاصيل البيبلوغرافية
العنوان: Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus, Denmark, 2020-2023.
المؤلفون: Arendrup MC, Hare RK, Jørgensen KM, Bollmann UE, Bech TB, Hansen CC, Heick TM, Jørgensen LN
المصدر: Emerging infectious diseases [Emerg Infect Dis] 2024 Aug; Vol. 30 (8), pp. 1531-1541. Date of Electronic Publication: 2024 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
مواضيع طبية MeSH: Aspergillus fumigatus*/drug effects , Aspergillus fumigatus*/genetics , Aspergillus fumigatus*/isolation & purification , Azoles*/pharmacology , Drug Resistance, Fungal* , Antifungal Agents*/pharmacology, Denmark/epidemiology ; Humans ; Aspergillosis/epidemiology ; Aspergillosis/microbiology ; Aspergillosis/drug therapy ; Microbial Sensitivity Tests ; Mutation ; Fungicides, Industrial/pharmacology ; Genotype
مستخلص: Azole-resistant Aspergillus fumigatus (ARAf) fungi have been found inconsistently in the environment in Denmark since 2010. During 2018-2020, nationwide surveillance of clinical A. fumigatus fungi reported environmental TR 34 /L98H or TR 46 /Y121F/T289A resistance mutations in 3.6% of isolates, prompting environmental sampling for ARAf and azole fungicides and investigation for selection of ARAf in field and microcosmos experiments. ARAf was ubiquitous (20% of 366 samples; 16% TR 34 /L98H- and 4% TR 46 /Y121F/T289A-related mechanisms), constituting 4.2% of 4,538 A. fumigatus isolates. The highest proportions were in flower- and compost-related samples but were not correlated with azole-fungicide application concentrations. Genotyping showed clustering of tandem repeat-related ARAf and overlaps with clinical isolates in Denmark. A. fumigatus fungi grew poorly in the field experiment with no postapplication change in ARAf proportions. However, in microcosmos experiments, a sustained complete (tebuconazole) or partial (prothioconazole) inhibition against wild-type A. fumigatus but not ARAf indicated that, under some conditions, azole fungicides may favor growth of ARAf in soil.
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فهرسة مساهمة: Keywords: A. fumigatus; ARAF; Aspergillus fumigatus; Denmark; agriculture; aspergillosis; azole fungicide; azole resistance; compost; flower bed; fungi; horticulture; manure heap; microsatellite typing
المشرفين على المادة: 0 (Azoles)
0 (Antifungal Agents)
0 (Fungicides, Industrial)
تواريخ الأحداث: Date Created: 20240627 Date Completed: 20240722 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC11286046
DOI: 10.3201/eid3008.240096
PMID: 38935978
قاعدة البيانات: MEDLINE
الوصف
تدمد:1080-6059
DOI:10.3201/eid3008.240096