دورية أكاديمية
Recovery of Social Continence and Sexual Function in Men With High-risk Prostate Cancer After Radical Prostatectomy: Results From a Statewide Collaborative.
| العنوان: | Recovery of Social Continence and Sexual Function in Men With High-risk Prostate Cancer After Radical Prostatectomy: Results From a Statewide Collaborative. |
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| المؤلفون: | Triner D; Department of Urology, Michigan Medicine, Ann Arbor, MI. Electronic address: trinerda@med.umich.edu., Johnson K; Department of Urology, Levine Cancer Institute, Atrium Health, Charlotte, NC., Meah S; Department of Urology, Michigan Medicine, Ann Arbor, MI., Daignault-Newton S; Department of Urology, Michigan Medicine, Ann Arbor, MI., Vaishampayan N; Department of Urology, Michigan Medicine, Ann Arbor, MI., Dhir A; Department of Urology, Michigan Medicine, Ann Arbor, MI., Labardee C; Department of Urology, Michigan Medicine, Ann Arbor, MI., Ferrante S; Department of Urology, Michigan Medicine, Ann Arbor, MI., Ginsburg KB; Department of Urology, Wayne State University School of Medicine, Detroit, MI., Lane BR; Division of Urology, Corewell Health Hospital System, Grand Rapids, MI., George AK; Brady Urological Institute, Johns Hopkins University, Baltimore, MD., Semerjian A; Department of Urology, Michigan Medicine, Ann Arbor, MI. |
| مؤلفون مشاركون: | Michigan Urological Surgery Improvement Collaborative |
| المصدر: | Urology [Urology] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0366151 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-9995 (Electronic) Linking ISSN: 00904295 NLM ISO Abbreviation: Urology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Science Original Publication: Ridgewood, N.J., Professional Medical Services Co. |
| مستخلص: | Objectives: To examine post-operative urinary and sexual functional outcomes for men with high-risk prostate cancer (HRPCa) who underwent radical prostatectomy (RP) within the Michigan Urological Surgery Improvement Collaborative (MUSIC). Methods: We identified patients who underwent RP for HRPCa in MUSIC between 2014 and 2023. HRPCa was defined according to American Urological Association criteria. Patients completed Expanded Prostate Cancer Index Composite (EPIC-26) pre-RP and 3-, 6-, 12-, and 24-months postoperatively. Primary outcomes included social continence, defined as 0-1 pads used daily; and recovery of sexual function, defined as the ability to achieve erections firm enough for intercourse. Multivariable and bivariate analyses were performed to identify factors associated with recovery of social continence and sexual function. Results: Around 1323 patients were included in the post-RP urinary continence analysis and 422 men in the sexual function analysis. Fifty-eight percent and 86% of patients achieved social continence at 3- and 12-months post-RP, respectively. Continence recovery was associated with higher baseline EPIC-26 urinary continence scores (OR 1.10, per 5 points, 95% CI 1.06-1.15, P <.001), and negatively associated with increasing age (OR 0.78 per 5-year increase, 95% CI 0.71-0.85 P <.001). Fifteen percent of patients had recovery of sexual function at 12-month post-RP. On bivariate analysis, recovery of sexual function was associated with nerve-sparing at time of RP, lower pre-operative PSA, and not receiving post-RP ADT/RT. Conclusion: RP for HRPCa has acceptable rates of postoperative social continence. However, post-RP recovery of sexual function remains a challenge. This information has important implications for pre-operative counseling and post-operative follow-up for patients with HRPCa. Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20240627 Latest Revision: 20240706 |
| رمز التحديث: | 20240707 |
| DOI: | 10.1016/j.urology.2024.06.018 |
| PMID: | 38936624 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1527-9995 |
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| DOI: | 10.1016/j.urology.2024.06.018 |