دورية أكاديمية
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Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits.

التفاصيل البيبلوغرافية
العنوان: Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits.
المؤلفون: Martini APR; Graduate Program in Neuroscience, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Schlemmer LM; Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Graduate Program in Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Lucio Padilha JA; Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Graduate Program in Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Fabres RB; Department of Pediatrics, NorthShore University HealthSystem, Evanston, IL, United States.; Pritzker School of Medicine, University of Chicago, Chicago, IL, United States., Couto Pereira NS; Psychological Neuroscience Laboratory, Psychology Research Center, School of Psychology, University of Minho, Braga, Portugal., Pereira LO; Graduate Program in Neuroscience, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Dalmaz C; Graduate Program in Neuroscience, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Graduate Program in Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Netto CA; Graduate Program in Neuroscience, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Department of Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Graduate Program in Biochemistry, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
المصدر: Frontiers in rehabilitation sciences [Front Rehabil Sci] 2024 Jun 13; Vol. 5, pp. 1375561. Date of Electronic Publication: 2024 Jun 13 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Country of Publication: Switzerland NLM ID: 9918227358906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-6861 (Electronic) Linking ISSN: 26736861 NLM ISO Abbreviation: Front Rehabil Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers, [2020]-
مستخلص: Background: Chronic cerebral hypoperfusion (CCH) leads to memory and learning impairments associated with degeneration and gliosis in the hippocampus. Treatment with physical exercise carries different therapeutic benefits for each sex. We investigated the effects of acrobatic training on astrocyte remodeling in the CA1 and CA3 subfields of the hippocampus and spatial memory impairment in male and female rats at different stages of the two-vessel occlusion (2VO) model.
Methods: Wistar rats were randomly allocated into four groups of males and females: 2VO acrobatic, 2VO sedentary, sham acrobatic, and sham sedentary. The acrobatic training was performed for 4 weeks prior to the 2VO procedure. Brain samples were collected for morphological and biochemical analysis at 3 and 7 days after 2VO. The dorsal hippocampi were removed and prepared for Western blot quantification of Akt, p-Akt, COX IV, cleaved caspase-3, PARP, and GFAP. GFAP immunofluorescence was performed on slices of the hippocampus to count astrocytes and apply the Sholl's circle technique. The Morris water maze was run after 45 days of 2VO.
Results: Acutely, the trained female rats showed increased PARP expression, and the 2VO-trained rats of both sexes presented increased GFAP levels in Western blot. Training, mainly in males, induced an increase in the number of astrocytes in the CA1 subfield. The 2VO rats presented branched astrocytes, while acrobatic training prevented branching. However, the 2VO-induced spatial memory impairment was partially prevented by the acrobatic training.
Conclusion: Acrobatic training restricted the astrocytic remodeling caused by 2VO in the CA1 and CA3 subfields of the hippocampus. The improvement in spatial memory was associated with more organized glial scarring in the trained rats and better cell viability observed in females.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(© 2024 Martini, Schlemmer, Lucio Padilha, Fabres, Couto Pereira, Pereira, Dalmaz and Netto.)
References: Hippocampus. 2015 Jul;25(7):813-26. (PMID: 25530343)
J Neurosci. 2009 Jul 29;29(30):9553-62. (PMID: 19641118)
Neuropharmacology. 2018 May 15;134(Pt B):226-239. (PMID: 29273521)
J Neurosci Methods. 1984 May;11(1):47-60. (PMID: 6471907)
Neurochem Int. 2015 Apr-May;83-84:1-8. (PMID: 25777481)
Alzheimers Dement. 2018 Sep;14(9):1171-1183. (PMID: 29907423)
Cold Spring Harb Perspect Biol. 2014 Nov 07;7(2):a020420. (PMID: 25380660)
Neurobiol Aging. 2000 Mar-Apr;21(2):225-33. (PMID: 10867207)
FEBS Lett. 2001 Feb 16;490(3):110-6. (PMID: 11223025)
Front Cell Neurosci. 2020 May 20;14:130. (PMID: 32508596)
Neural Plast. 2015;2015:370432. (PMID: 26257960)
Brain Res. 2005 Aug 2;1052(1):28-39. (PMID: 16023090)
Front Neuroendocrinol. 2017 Jul;46:71-85. (PMID: 28442274)
Life Sci. 2012 Jul 26;91(1-2):29-36. (PMID: 22683434)
Brain Res Rev. 2007 Apr;54(1):162-80. (PMID: 17296232)
Dialogues Clin Neurosci. 2016 Dec;18(4):437-446. (PMID: 28179815)
Mayo Clin Proc. 2011 Sep;86(9):876-84. (PMID: 21878600)
Exp Neurol. 2011 Jan;227(1):53-61. (PMID: 20850433)
Front Aging Neurosci. 2014 Nov 27;6:322. (PMID: 25505884)
Cells. 2021 Jun 18;10(6):. (PMID: 34207393)
Aging Dis. 2021 Oct 1;12(7):1644-1657. (PMID: 34631212)
Behav Brain Res. 2022 Jul 26;430:113935. (PMID: 35605797)
J Cell Biol. 2000 Oct 30;151(3):483-94. (PMID: 11062251)
Neuroreport. 1998 Jan 5;9(1):161-6. (PMID: 9592069)
Neuroscience. 2019 Dec 15;423:38-54. (PMID: 31682945)
Bioessays. 2004 Dec;26(12):1268-71. (PMID: 15551264)
Brain Res Bull. 2012 Jan 4;87(1):109-16. (PMID: 22040859)
J Neuroinflammation. 2020 Apr 16;17(1):117. (PMID: 32299450)
Cell Commun Signal. 2010 Dec 22;8:31. (PMID: 21176168)
J Cereb Blood Flow Metab. 2016 Sep;36(9):1592-602. (PMID: 26661170)
Physiol Int. 2019 Mar 1;106(1):21-28. (PMID: 30888219)
J Neurosci Methods. 1980 Dec;3(2):129-49. (PMID: 6110810)
Front Cell Neurosci. 2017 Dec 22;11:404. (PMID: 29311834)
J Alzheimers Dis. 2021;84(3):917-935. (PMID: 34633316)
Metab Brain Dis. 2022 Oct;37(7):2315-2329. (PMID: 35778625)
Front Mol Neurosci. 2022 Apr 01;15:860959. (PMID: 35431804)
J Cereb Blood Flow Metab. 2013 Jun;33(6):872-9. (PMID: 23423187)
Brain Sci. 2021 Mar 22;11(3):. (PMID: 33810204)
Braz J Med Biol Res. 2010 Dec;43(12):1178-83. (PMID: 21085899)
J Cereb Blood Flow Metab. 2014 Oct;34(10):1673-80. (PMID: 25052554)
Front Mol Neurosci. 2019 May 28;12:134. (PMID: 31191245)
Front Rehabil Sci. 2022 Sep 01;3:953822. (PMID: 36439550)
Exp Gerontol. 2017 Oct 1;96:46-62. (PMID: 28606482)
Cold Spring Harb Perspect Biol. 2015 Nov 02;7(11):. (PMID: 26525152)
J Neurochem. 2008 Jul;106(2):578-90. (PMID: 18410506)
Front Physiol. 2019 Dec 18;10:1508. (PMID: 31956310)
Proc Natl Acad Sci U S A. 1990 Jul;87(14):5568-72. (PMID: 1695380)
Neuropathology. 2000 Sep;20 Suppl:S95-7. (PMID: 11037198)
J Neurosci Res. 2019 Sep;97(9):1081-1094. (PMID: 31175682)
Neurol Res. 2014 Jul;36(7):627-33. (PMID: 24620966)
Mol Neurobiol. 2017 Jul;54(5):3670-3682. (PMID: 27206432)
Neuroscience. 2015 Dec 17;311:308-21. (PMID: 26518459)
Nat Neurosci. 2021 Mar;24(3):312-325. (PMID: 33589835)
Life Sci. 2021 Aug 1;278:119526. (PMID: 33894268)
Behav Brain Res. 2024 May 8;465:114941. (PMID: 38447760)
Front Mol Neurosci. 2021 Aug 19;14:710303. (PMID: 34489641)
Brain Res. 2011 Nov 3;1421:1-10. (PMID: 21974860)
J Cereb Blood Flow Metab. 2015 Aug;35(8):1249-59. (PMID: 25853908)
Brain Res. 2019 Mar 15;1707:27-44. (PMID: 30448443)
Prog Brain Res. 1985;63:29-37. (PMID: 2872695)
Int J Dev Neurosci. 2019 Aug;76:41-51. (PMID: 31202867)
Front Cell Dev Biol. 2022 Mar 03;10:798826. (PMID: 35309929)
Neuroscience. 1993 May;54(1):69-92. (PMID: 8515847)
Brain Res. 2014 Oct 31;1587:119-26. (PMID: 25192647)
Front Aging Neurosci. 2022 Jun 01;14:866336. (PMID: 35721009)
Neurobiol Learn Mem. 2012 Jan;97(1):90-6. (PMID: 22001013)
Mol Brain. 2019 May 9;12(1):48. (PMID: 31072410)
فهرسة مساهمة: Keywords: acrobatic exercise; astrogliosis; chronic cerebral hypoperfusion; cognitive damage; hippocampus; sexual dimorphism
تواريخ الأحداث: Date Created: 20240628 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11208732
DOI: 10.3389/fresc.2024.1375561
PMID: 38939055
قاعدة البيانات: MEDLINE
الوصف
تدمد:2673-6861
DOI:10.3389/fresc.2024.1375561