دورية أكاديمية
أعرض في EDS

Risk Factors for Death or Transplant After Stage 2 Palliation for Single Ventricle Heart Disease.

التفاصيل البيبلوغرافية
العنوان: Risk Factors for Death or Transplant After Stage 2 Palliation for Single Ventricle Heart Disease.
المؤلفون: Bucholz EM; Section of Cardiology, Department of Pediatrics, Children's Hospital of Colorado and the University of Colorado School of Medicine, Denver, Colorado, USA., Lu M; Department of Cardiology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA., Sleeper L; Department of Cardiology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA., Vergales J; Division of Pediatric Cardiology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Bingler MA; National Pediatric Cardiology Quality Improvement Collaborative., Ronai C; Department of Cardiology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA., Anderson JB; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Bates KE; Congenital Heart Center, University of Michigan C.S. Mott Children's Hospital, Ann Arbor, Michigan, USA., Lannon C; Congenital Heart Center, University of Michigan C.S. Mott Children's Hospital, Ann Arbor, Michigan, USA., Reynolds L; Department of Cardiology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA., Brown DW; Department of Cardiology, Boston Children's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
المصدر: JACC. Advances [JACC Adv] 2024 Apr 10; Vol. 3 (5), pp. 100934. Date of Electronic Publication: 2024 Apr 10 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918419284106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-963X (Electronic) Linking ISSN: 2772963X NLM ISO Abbreviation: JACC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2022]-
مستخلص: Background: For infants with single ventricle heart disease, the time after stage 2 procedure (S2P) is believed to be a lower risk period compared with the interstage period; however, significant morbidity and mortality still occur.
Objectives: This study aimed to identify risk factors for mortality or transplantation referral between S2P surgery and the first birthday.
Methods: Retrospective cohort analysis of infants in the National Pediatric Cardiology Quality Improvement Collaborative who underwent staged single ventricle palliation from 2016 to 2022 and survived to S2P. Multivariable logistic regression and classification and regression trees were performed to identify risk factors for mortality and transplantation referral after S2P.
Results: Of the 1,455 patients in the cohort who survived to S2P, 5.2% died and 2.3% were referred for transplant. Overall event rates at 30 and 100 days after S2P were 2% and 5%, respectively. Independent risk factors for mortality and transplantation referral included the presence of a known genetic syndrome, shunt type at stage 1 procedure (S1P), tricuspid valve repair at S1P, longer time to extubation and reintubation after S1P, ≥ moderate tricuspid regurgitation prior to S2P, younger age at S2P, and the risk groups identified in the classification and regression tree analysis (extracorporeal membrane oxygenation after S1P and longer S2P cardiopulmonary bypass time without extracorporeal membrane oxygenation).
Conclusions: Mortality and transplantation referral rates after S2P to 1 year of age remain high ∼7%. Many of the identified risk factors after S2P are similar to those established for interstage factors around the S1P, whereas others may be unique to the period after S2P.
Competing Interests: Dr Bucholz is funded by a grant from the 10.13039/100005627Thrasher Research Fund to apply machine learning techniques for risk prediction of outcomes in single ventricle heart disease. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
(© 2024 The Authors.)
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فهرسة مساهمة: Keywords: Glenn palliation; hypoplastic left heart syndrome; outcome prediction; single ventricle heart disease
تواريخ الأحداث: Date Created: 20240628 Latest Revision: 20240629
رمز التحديث: 20240629
مُعرف محوري في PubMed: PMC11198479
DOI: 10.1016/j.jacadv.2024.100934
PMID: 38939642
قاعدة البيانات: MEDLINE
الوصف
تدمد:2772-963X
DOI:10.1016/j.jacadv.2024.100934