دورية أكاديمية
Palladium-Catalyzed/Copper-Mediated Decarbonylative Cross-Coupling of S -Pyrimidyl Thioesters for Biaryl Synthesis.
| العنوان: | Palladium-Catalyzed/Copper-Mediated Decarbonylative Cross-Coupling of S -Pyrimidyl Thioesters for Biaryl Synthesis. |
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| المؤلفون: | Jin YH; Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea., Lee J; Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea., Kim J; Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea., Sohn JH; Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea. |
| المصدر: | The Journal of organic chemistry [J Org Chem] 2024 Jul 19; Vol. 89 (14), pp. 9800-9809. Date of Electronic Publication: 2024 Jun 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Publication: Columbus Oh : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مستخلص: | A palladium-catalyzed/copper-mediated cross-coupling of S -pyrimidinyl thioesters with arylboronic acids to yield biaryls is described. The reaction is likely to proceed via cleavage of the S-C(O) bond and subsequent release of CO, rather than via cleavage of the S-C(pyrimidine) bond and release of SCO, as supported by the results of both experimental and computational studies. The investigation of the reaction scope with various S -pyrimidinyl thioesters and arylboronic acids showed that the reaction is significantly affected by the substituent of the thioester and the presence of a chelatable ortho substituent was found to increase reaction efficiency. |
| تواريخ الأحداث: | Date Created: 20240628 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| DOI: | 10.1021/acs.joc.4c00252 |
| PMID: | 38940361 |
| قاعدة البيانات: | MEDLINE |
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