دورية أكاديمية
Combination of Callyspongia sp. and Stem Cells for Wound Repair and Skin Regeneration: in Vivo and in Silico Evidences.
| العنوان: | Combination of Callyspongia sp. and Stem Cells for Wound Repair and Skin Regeneration: in Vivo and in Silico Evidences. |
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| المؤلفون: | Maher Zahran E; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Abdelwahab MF; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt., Mohyeldin RH; Department of Pharmacology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Tammam OY; Department of Biochemistry, Faculty of Pharmacy, New Valley University, New Valley, Egypt., Abdel-Maqsoud NMR; Department of Medical Science (Pathology), Deraya University, Minia, 61111, Egypt., Altemani FH; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia., Algehainy NA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia., Alanazi MA; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia., Jalal MM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia., Elrehany MA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Bringmann G; Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany., Ramadan Abdelmohsen U; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2024 Jun 28, pp. e202400682. Date of Electronic Publication: 2024 Jun 28. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مستخلص: | Delayed healing of chronic wounds results in amputation and mortality rates in serious cases. The present study examines the merged wound-restorative efficacy of injectable bone marrow-derived mesenchymal stem cells (BMMSCs) and topical Callyspongia sp. extract in immunocompromised rats. HR-LC-MS analysis of Callyspongia sp. extract tentatively identified twenty-nine compounds (1-29) and highlighted its richness in fatty acids and terpenoids, known for their wound regenerating efficacies. The wound closure was greatly prominent in the BMMSCs/Callyspongia sp. group in contrast to the control group (p<0.001). The RT-PCR gene expression emphasized these results by attenuating the oxidative, inflammatory, and immunity markers, further confirmed by histopathological findings. Additionally, in silico modeling was particularly targeting matrix metalloproteinase-9 (MMP9), a key player in wound healing processes. Computational analysis revealed that compounds 18 and 19 potentially modulate MMP9 activity. The combination of BMMSCs and topical Callyspongia sp. extract holds a promise for regenerative therapy constituting a drastic advance in the wound cure of immunocompromised patients, eventually further safety assessments and clinical trials are required. (© 2024 Wiley-VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | Deraya University |
| فهرسة مساهمة: | Keywords: Callyspongia sp.; Immunity; Immunocompromization; Pro-inflammatory cytokines; Stem cells |
| تواريخ الأحداث: | Date Created: 20240628 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| DOI: | 10.1002/cbdv.202400682 |
| PMID: | 38941178 |
| قاعدة البيانات: | MEDLINE |
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