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Escalation by duplication: Milkweed bug trumps Monarch butterfly.

التفاصيل البيبلوغرافية
العنوان: Escalation by duplication: Milkweed bug trumps Monarch butterfly.
المؤلفون: Beran F; Population Ecology Group, Friedrich-Schiller Universität Jena, Jena, Germany.; Department of Insect Symbiosis, Max Planck Institute for Chemical Ecology, Jena, Germany., Heckel DG; Emeritus Group Entomology, Max Planck Institute for Chemical Ecology, Jena, Germany.
المصدر: Molecular ecology [Mol Ecol] 2024 Jul; Vol. 33 (14), pp. e17443. Date of Electronic Publication: 2024 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992-
مواضيع طبية MeSH: Butterflies*/genetics , Sodium-Potassium-Exchanging ATPase*/genetics , Sodium-Potassium-Exchanging ATPase*/metabolism , Asclepias*/genetics , Asclepias*/chemistry, Animals ; Cardenolides ; Gene Duplication ; Cardiac Glycosides/pharmacology ; Larva
مستخلص: The iconic Monarch butterfly is probably the best-known example of chemical defence against predation, as pictures of vomiting naive blue jays in countless textbooks vividly illustrate. Larvae of the butterfly take up toxic cardiac glycosides from their milkweed hostplants and carry them over to the adult stage. These compounds (cardiotonic steroids, including cardenolides and bufadienolides) inhibit the animal transmembrane sodium-potassium ATPase (Na,K-ATPase), but the Monarch enzyme resists this inhibition thanks to amino acid substitutions in its catalytic alpha-subunit. Some birds also have substitutions and can feast on cardiac glycoside-sequestering insects with impunity. A flurry of recent work has shown how the alpha-subunit gene has been duplicated multiple times in separate insect lineages specializing in cardiac glycoside-producing plants. In this issue of Molecular Ecology, Herbertz et al. toss the beta-subunit into the mix, by expressing all nine combinations of three alpha- and three beta-subunits of the milkweed bug Na,K-ATPase and testing their response to a cardenolide from the hostplant. The findings suggest that the diversification and subfunctionalization of genes allow milkweed bugs to balance trade-offs between resistance towards sequestered host plant toxins that protect the bugs from predators, and physiological costs in terms of Na,K-ATPase activity.
(© 2024 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd.)
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Herbertz, M., Harder, S., Schlüter, H., Lohr, C., & Dobler, S. (2022). Na,K‐ATPase α1 and β‐subunits show distinct localizations in the nervous tissue of the large milkweed bug. Cell and Tissue Research, 388(3), 503–519.
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فهرسة مساهمة: Keywords: adaptation; coevolution; ecological genetics; insects; invertebrates; molecular evolution
المشرفين على المادة: EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
0 (Cardenolides)
0 (Cardiac Glycosides)
تواريخ الأحداث: Date Created: 20240629 Date Completed: 20240708 Latest Revision: 20240708
رمز التحديث: 20240708
DOI: 10.1111/mec.17443
PMID: 38943372
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-294X
DOI:10.1111/mec.17443