دورية أكاديمية
Discovery of Oxidized p -Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi.
| العنوان: | Discovery of Oxidized p -Terphenyls as Phosphodiesterase 4 Inhibitors from Marine-Derived Fungi. |
|---|---|
| المؤلفون: | Cai J; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhou Q; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Qi X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China., Zhang F; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Yang J; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Chen C; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhang K; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Chen Z; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Luo HB; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Liu Y; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China., Huang YY; Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.; Song Li' Academician Workstation of Hainan University (School of Pharmaceutical Sciences), Yazhou Bay, Sanya 572000, China., Zhou X; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.; University of Chinese Academy of Sciences, Beijing 100049, China. |
| المصدر: | Journal of natural products [J Nat Prod] 2024 Jul 26; Vol. 87 (7), pp. 1808-1816. Date of Electronic Publication: 2024 Jun 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Phosphodiesterase 4 Inhibitors*/pharmacology , Phosphodiesterase 4 Inhibitors*/chemistry , Phosphodiesterase 4 Inhibitors*/isolation & purification , Terphenyl Compounds*/pharmacology , Terphenyl Compounds*/chemistry , Terphenyl Compounds*/isolation & purification, Mice ; Animals ; Molecular Structure ; Talaromyces/chemistry ; RAW 264.7 Cells ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Marine Biology |
| مستخلص: | Four new p -terphenyl derivatives, talaroterphenyls A-D ( 1 - 4 ), together with three biosynthetically related known ones ( 5 - 7 ), were obtained from the mangrove sediment-derived Talaromyces sp. SCSIO 41412. Compounds 1 - 3 are rare p -terphenyls, which are completely substituted on the central benzene ring by oxygen atoms; this is the first report of their isolation from natural sources. Their structures were elucidated through NMR spectroscopy, HRESIMS, and X-ray diffraction. Genome sequence analysis revealed that 1 - 7 were biosynthesized from tyrosine and phenylalanine, involving four key biosynthetic genes ( ttpB - ttpE ). These p -terphenyls ( 1 - 7 ) and 36 marine-derived terphenyl analogues ( 8 - 43 ) were screened for phosphodiesterase 4 (PDE4) inhibitory activities, and 1 - 5 , 14 , 17 , 23 , and 26 showed notable activities with IC |
| المشرفين على المادة: | 0 (Phosphodiesterase 4 Inhibitors) 0 (Terphenyl Compounds) EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4) |
| تواريخ الأحداث: | Date Created: 20240629 Date Completed: 20240726 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1021/acs.jnatprod.4c00422 |
| PMID: | 38943602 |
| قاعدة البيانات: | MEDLINE |
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