دورية أكاديمية
Development of biopolymer films loaded with fluconazole and thymol for resistant vaginal candidiasis.
| العنوان: | Development of biopolymer films loaded with fluconazole and thymol for resistant vaginal candidiasis. |
|---|---|
| المؤلفون: | Conte J; Postgraduate Program in Pharmacy (PGFAR), Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., Saatkamp RH; Postgraduate Program in Chemistry, Chemistry Department, Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., Sanches MP; Postgraduate Program in Chemistry, Chemistry Department, Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., Argenta DF; Postgraduate Program in Pharmacy (PGFAR), Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., da Rosa Monte Machado G; Postgraduate Program in Pharmacy (PGFAR), Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., Kretzer IF; Postgraduate Program in Pharmacy (PGFAR), Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., Parize AL; Postgraduate Program in Chemistry, Chemistry Department, Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil., Caon T; Postgraduate Program in Pharmacy (PGFAR), Federal University of Santa Catarina, Trindade, 88040-900 Florianopolis, SC, Brazil. Electronic address: caon.thiago@ufsc.br. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun 26, pp. 133356. Date of Electronic Publication: 2024 Jun 26. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مستخلص: | Vulvovaginal candidiasis (VVC) is an opportunistic infection caused by a fungus of the Candida genus, affecting approximately 75 % of women during their lifetime. Fungal resistance cases and adverse effects have been the main challenges of oral therapies. In this study, the topical application of thin films containing fluconazole (FLU) and thymol (THY) was proposed to overcome these problems. Vaginal films based only on chitosan (CH) or combining this biopolymer with pectin (PEC) or hydroxypropylmethylcellulose acetate succinate (HPMCAS) were developed by the solvent casting method. In addition to a higher swelling index, CH/HPMCAS films showed to be more plastic and flexible than systems prepared with CH/PEC or only chitosan. Biopolymers and FLU were found in an amorphous state, contributing to explaining the rapid gel formation after contact with vaginal fluid. High permeability rates of FLU were also found after its immobilization into thin films. The presence of THY in polymer films increased the distribution of FLU in vaginal tissues and resulted in improved anti-Candida activity. A significant activity against the resistant C. glabrata was achieved, reducing the required FLU dose by 50 %. These results suggest that the developed polymer films represent a promising alternative for the treatment of resistant vulvovaginal candidiasis, encouraging further studies in this context. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors also thank Professor Adailton Bortoluzzi for his help with XRD analyses. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chitosan; Fluconazole; Hydroxypropylmethylcellulose acetate succinate; Pectin; Polymeric films; Vaginal candidiasis |
| تواريخ الأحداث: | Date Created: 20240630 Latest Revision: 20240630 |
| رمز التحديث: | 20240701 |
| DOI: | 10.1016/j.ijbiomac.2024.133356 |
| PMID: | 38945715 |
| قاعدة البيانات: | MEDLINE |
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