دورية أكاديمية
Bioactive pH-sensitive nanoemulsion in melanoma cell lines.
| العنوان: | Bioactive pH-sensitive nanoemulsion in melanoma cell lines. |
|---|---|
| المؤلفون: | Forte J; Department of Drug Chemistry and Technology, Sapienza University of Rome, Rome 00161, Italy. Electronic address: jacopo.forte@uniroma.it., Gioia Fabiano M; Department of Drug Chemistry and Technology, Sapienza University of Rome, Rome 00161, Italy. Electronic address: mariagioia.fabiano@uniroma1.it., Grazia Ammendolia M; National Center for Innovative Technologies in Public Health, Istituto Superiore di Sanità, Rome 00161, Italy. Electronic address: maria.ammendolia@iss.it., Puglisi R; Center for Gender-specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy. Electronic address: rossella.puglisi@iss.it., Rinaldi F; Department of Drug Chemistry and Technology, Sapienza University of Rome, Rome 00161, Italy. Electronic address: federica.rinaldi@uniroma1.it., Ricci C; Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università di Milano, Milan, Italy. Electronic address: caterina.ricci@unimi.it., Del Favero E; Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università di Milano, Milan, Italy. Electronic address: elena.delfavero@unimi.it., Carafa M; Department of Drug Chemistry and Technology, Sapienza University of Rome, Rome 00161, Italy. Electronic address: maria.carafa@uniroma1.it., Mattia G; Center for Gender-specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy. Electronic address: gianfranco.mattia@iss.it., Marianecci C; Department of Drug Chemistry and Technology, Sapienza University of Rome, Rome 00161, Italy. Electronic address: carlotta.marianecci@uniroma1.it. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2024 Aug 15; Vol. 661, pp. 124380. Date of Electronic Publication: 2024 Jun 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Emulsions* , Curcumin*/administration & dosage , Curcumin*/chemistry , Curcumin*/pharmacology , Oleic Acid*/chemistry , Melanoma, Experimental*/drug therapy , Nanoparticles*/chemistry, Hydrogen-Ion Concentration ; Cell Line, Tumor ; Animals ; Mice ; Drug Carriers/chemistry ; Cell Survival/drug effects ; Melanoma/drug therapy ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Drug Delivery Systems |
| مستخلص: | Melanoma is an aggressive form of skin cancer with elevated propensity to metastasize. One of the major critical issues in the treatment of oncological patients is represented by the development of toxicity and resistance to the available therapies. Great progress has been made in the field of nanotechnologies to limit the unwanted effects of anti-cancer treatments. We explored the potential of creating oil-in-water nanoemulsions composed of oleic acid, as a bioactive carrier for lipophilic drug delivery. This bioactive nanoemulsion was loaded with Curcumin, a natural fluorescent lipophilic compound, used as a model drug to evaluate nanoemulsion capability to: i) encapsulate the lipophilic moiety; ii) interact with the specific cells, and iii) improve the efficacy of the loaded model drug compared to the free one. Therefore, we evaluated the physical-chemical features of Curcumin-loaded nanoemulsions, confirming their pH sensibility and their stability over time. Moreover, the nanoemulsions were able to preserve the loaded Curcumin by degradation/destabilization phenomena. Finally, we verified some of the biological functions of Curcumin delivered by nanoemulsions in the B16F10 melanoma cell line. We obtained evidence of the biological action of Curcumin, suggesting oleic-based nanoemulsions as an efficient nanocarrier for lipophilic drug delivery. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Curcumin; Drug delivery; Melanoma; Metastatization; Nanoemulsions; pH sensitivity |
| المشرفين على المادة: | 0 (Emulsions) IT942ZTH98 (Curcumin) 2UMI9U37CP (Oleic Acid) 0 (Drug Carriers) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20240701 Date Completed: 20240731 Latest Revision: 20240731 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1016/j.ijpharm.2024.124380 |
| PMID: | 38950661 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
|---|---|
| DOI: | 10.1016/j.ijpharm.2024.124380 |