دورية أكاديمية
أعرض في EDS

Embryotoxicity and teratogenesis of orthodontic acrylic resin in zebrafish.

التفاصيل البيبلوغرافية
العنوان: Embryotoxicity and teratogenesis of orthodontic acrylic resin in zebrafish.
المؤلفون: Sayuri Cardoso Ohashi A; Dental Program, School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Reis de Souza Schacher H; Dental Program, School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Staub Pizzato C; ZebLab & Laboratory of Biology and Development of the Nervous System, School of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Ryff Moreira Roca Vianna M; ZebLab & Laboratory of Biology and Development of the Nervous System, School of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil., Macedo de Menezes L; Dental Program, School of Health and Life Sciences Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
المصدر: Heliyon [Heliyon] 2024 Jun 07; Vol. 10 (12), pp. e32067. Date of Electronic Publication: 2024 Jun 07 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Objectives: This study investigated the in vivo embryotoxicity, teratogenic potential, and additional effects of orthodontic acrylic resin as well as its components, utilizing zebrafish as a model organism. The research focused on morphological, cardiac, behavioral, and cognitive evaluations that were performed on embryos and larval-stage animals subjected to chronic exposure.
Materials and Methods: Embryo and larval-stage zebrafish were categorized into five experimental groups, which were further subdivided into five subgroups. These subgroups included three specific doses for each tested substance, a control with the vehicle (0.1 % dimethyl sulfoxide in water), and an absolute control (water). Assessments were performed on day 5 post-fertilization, which included morphological, cardiac, behavioral, and cognitive evaluations. All experiments had a sample size of ten animals and were performed in triplicate. Survival and hatching rates were analyzed using the Kaplan-Meier test, while other measurements were assessed using one-way analysis of variance (ANOVA), followed by the Tukey post hoc test.
Results: Statistically significant differences were observed between the control and treatment groups across all the tested substances for heart rate, cognitive responsiveness, and cellular apoptosis. However, survival, hatching rate, and other parameters exhibited no significant variation, except for the highest dose in the dibutyl phthalate group, which demonstrated a notable difference in survival.
Conclusions: Chronic exposure to acrylic resin and its components may be associated with decreased cognitive ability and cardiac rhythm, as well as an increase in the level of cellular apoptosis in zebrafish.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors. Published by Elsevier Ltd.)
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فهرسة مساهمة: Keywords: Animal model; Benzoyl peroxide; Dibutyl phthalate; Formaldehyde; Methyl methacrylate; Toxicity
تواريخ الأحداث: Date Created: 20240702 Latest Revision: 20240703
رمز التحديث: 20240703
مُعرف محوري في PubMed: PMC11215258
DOI: 10.1016/j.heliyon.2024.e32067
PMID: 38952375
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2024.e32067