دورية أكاديمية
Correlation between plasma biochemical parameters and cardio-hepatic iron deposition in thalassemia major patients.
| العنوان: | Correlation between plasma biochemical parameters and cardio-hepatic iron deposition in thalassemia major patients. |
|---|---|
| المؤلفون: | Saadatifar H; Department of Echocardiography, Dezful University of Medical Sciences, Dezful, Iran., Mard-Soltani M; Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran., Niayeshfar A; Department of Epidemiology, Dezful University of Medical Sciences, Dezful, Iran., Shakerian N; Department of Laboratory Sciences, Dezful University of Medical Sciences, Dezful, Iran., Pouriamehr S; Department of Laboratory Sciences, Dezful University of Medical Sciences, Dezful, Iran., Alinezhad Dezfuli D; Department of Laboratory Sciences, Dezful University of Medical Sciences, Dezful, Iran., Khalili S; Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran., Saadatifar S; Pharmacist, Ahvaz University of Medical Sciences, Ahvaz, Iran., Mashhadi SM; Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
| المصدر: | Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2024 Jul; Vol. 84 (4), pp. 245-251. Date of Electronic Publication: 2024 Jul 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0404375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7686 (Electronic) Linking ISSN: 00365513 NLM ISO Abbreviation: Scand J Clin Lab Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Oslo, Medisinsk Fysiologisk Forenings Forlag. |
| مواضيع طبية MeSH: | beta-Thalassemia*/blood , beta-Thalassemia*/complications , Liver*/metabolism , Liver*/diagnostic imaging , Myocardium*/metabolism , Iron*/metabolism , Iron*/blood , Magnetic Resonance Imaging* , Ferritins*/blood, Humans ; Male ; Female ; Adult ; Adolescent ; Iron Overload/blood ; Iron Overload/metabolism ; Aspartate Aminotransferases/blood ; Young Adult ; Alanine Transaminase/blood ; Magnesium/blood ; Child ; Blood Glucose/metabolism |
| مستخلص: | Introduction: Major Thalassemia patients suffer from iron overload and organ damage, especially heart and liver damage. Early diagnosis and treatment with a chelator can reduce the complications and mortality of iron overload. Therefore, we aimed to investigate the biochemical and hematological predictors as an alternative and indirect indicator of iron deposition in heart and liver cells in comparison with the MRI T2* method as the gold standard. Material and Method: MRI T2* was evaluated in the heart and liver tissues of 62 major beta-thalassemia patients undergoing regular transfusion and chelator therapy. Biochemical and hematological factors were also measured, including serum ferritin, serum electrolytes, liver enzymes, hemoglobin, blood glucose, and serum magnesium. The correlation between these factors was assessed using statistical evaluations. Result: Serum ferritin had a positive and significant correlation with liver siderosis based on MRI T2* ( p -value = .015), and no significant association was observed with cardiac siderosis ( p -value = .79). However, there was a significant positive correlation between cardiac iron deposition and fasting blood sugar level ( p -value = -.049), and plasma level of liver enzymes (alanine aminotransferase (ALT) ( p -value = .001), aspartate aminotransferase (AST (( p -value = .01)). Moreover, there was a significant negative correlation between cardiac iron overload and plasma magnesium level ( p -value = .014). According to MRI T2*, there was no significant correlation between cardiac and hepatic iron overload ( p value = .36). Conclusion: An increase in blood sugar or liver enzymes and a decrease in serum magnesium was associated with an increase in cardiac iron overload based on MRI T2*. Liver iron overload based on MRI T2* had a significant correlation with serum ferritin. |
| فهرسة مساهمة: | Keywords: Beta-thalassemia; ferritin; iron overload; siderosis of the liver |
| المشرفين على المادة: | E1UOL152H7 (Iron) 9007-73-2 (Ferritins) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) I38ZP9992A (Magnesium) 0 (Blood Glucose) |
| تواريخ الأحداث: | Date Created: 20240702 Date Completed: 20240819 Latest Revision: 20240819 |
| رمز التحديث: | 20240820 |
| DOI: | 10.1080/00365513.2024.2369991 |
| PMID: | 38953608 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1502-7686 |
|---|---|
| DOI: | 10.1080/00365513.2024.2369991 |