دورية أكاديمية
أعرض في EDS

An rs-fMRI based neuroimaging marker for adult absence epilepsy.

التفاصيل البيبلوغرافية
العنوان: An rs-fMRI based neuroimaging marker for adult absence epilepsy.
المؤلفون: Liu R; Department of Neurology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China., Zhu G; Department of Medical Imaging, Heilongjiang Provincial Hospital, Harbin, China., Gao Y; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China., Li D; Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Department of Neurology and Neuroscience Center, Heilongjiang Provincial Hospital, Harbin, China. Electronic address: lidb0033@163.com.
المصدر: Epilepsy research [Epilepsy Res] 2024 Aug; Vol. 204, pp. 107400. Date of Electronic Publication: 2024 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8703089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6844 (Electronic) Linking ISSN: 09201211 NLM ISO Abbreviation: Epilepsy Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science Publishers, c1987-
مواضيع طبية MeSH: Magnetic Resonance Imaging*/methods , Epilepsy, Absence*/diagnostic imaging , Support Vector Machine*, Humans ; Male ; Female ; Adult ; Young Adult ; Thalamus/diagnostic imaging ; Brain/diagnostic imaging ; Neuroimaging/methods ; Putamen/diagnostic imaging ; Brain Mapping/methods ; Sensitivity and Specificity
مستخلص: Objective: Approximately 20-30 % of epilepsy patients exhibit negative findings on routine magnetic resonance imaging, and this condition is known as nonlesional epilepsy. Absence epilepsy (AE) is a prevalent form of nonlesional epilepsy. This study aimed to investigate the clinical diagnostic utility of regional homogeneity (ReHo) assessed through the support vector machine (SVM) approach for identifying AE.
Methods: This research involved 102 healthy individuals and 93 AE patients. Resting-state functional magnetic resonance imaging was employed for data acquisition in all participants. ReHo analysis, coupled with SVM methodology, was utilized for data processing.
Results: Compared to healthy control individuals, AE patients demonstrated significantly elevated ReHo values in the bilateral putamen, accompanied by decreased ReHo in the bilateral thalamus. SVM was used to differentiate patients with AE from healthy control individuals based on rs-fMRI data. A composite assessment of altered ReHo in the left putamen and left thalamus yielded the highest accuracy at 81.64 %, with a sensitivity of 95.41 % and a specificity of 69.23 %.
Significance: According to the results, altered ReHo values in the bilateral putamen and thalamus could serve as neuroimaging markers for AE, offering objective guidance for its diagnosis.
Competing Interests: Declaration of Competing Interest All authors declare that they have no conflict of interest.
(Copyright © 2024. Published by Elsevier B.V.)
التعليقات: Erratum in: Epilepsy Res. 2024 Jul 26:107420. doi: 10.1016/j.eplepsyres.2024.107420. (PMID: 39068092)
فهرسة مساهمة: Keywords: Absence epilepsy; Imaging biomarker; Regional homogeneity; Resting-state fMRI; Support vector machine
تواريخ الأحداث: Date Created: 20240702 Date Completed: 20240710 Latest Revision: 20240727
رمز التحديث: 20240728
DOI: 10.1016/j.eplepsyres.2024.107400
PMID: 38954950
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6844
DOI:10.1016/j.eplepsyres.2024.107400