دورية أكاديمية
أعرض في EDS

Skin graft surgery and its impact on platelet counts in Iranian burn patients: a non-randomized clinical trial.

التفاصيل البيبلوغرافية
العنوان: Skin graft surgery and its impact on platelet counts in Iranian burn patients: a non-randomized clinical trial.
المؤلفون: Kazemzadeh J; Reconstructive and Burn Surgery Department, Urmia University of Medical Sciences, Urmia, Iran., Pakzad S; Reconstructive and Burn Surgery Department, Urmia University of Medical Sciences, Urmia, Iran., Parizad N; Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran. parizad.n@umsu.ac.ir.; Nursing and Midwifery Faculty, Campus Nazlu, 11 KM Road Seru, Urmia, 575611-5111, West Azerbaijan, Iran. parizad.n@umsu.ac.ir., Jafari Y; Department of General surgery, Urmia University of Medical Sciences, Urmia, Iran.
المصدر: BMC surgery [BMC Surg] 2024 Jul 03; Vol. 24 (1), pp. 200. Date of Electronic Publication: 2024 Jul 03.
نوع المنشور: Journal Article; Clinical Trial
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968567 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2482 (Electronic) Linking ISSN: 14712482 NLM ISO Abbreviation: BMC Surg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Burns*/surgery , Burns*/blood , Skin Transplantation*/methods, Humans ; Female ; Male ; Iran/epidemiology ; Adult ; Platelet Count ; Middle Aged ; Young Adult ; Adolescent
مستخلص: Background: Platelets are critical in maintaining homeostasis and immune response in burn patients. The concentration of platelets decreases in burn patients, and any intervention that increases serum platelet concentration can prevent serious consequences and patient death. The present study aimed to assess the impact of skin graft surgery on burn patients' platelet counts.
Methods: In this non-randomized clinical trial, 200 burn patients were investigated. The patients were recruited from the surgical ward of Imam Khomeini Teaching Hospital during the first six months of 2021. After completing the checklist, patients underwent skin graft surgery. Blood was taken from the patients during surgery in the operating room and on the third and fifth day after the surgery to check platelets. Data analysis was conducted using SPSS software (ver. 22.0).
Results: Most patients (63.5%) were male, and 73 (36.5%) were female. One hundred eighty-one patients (90.5%) had deep burns, and 19 (9.5%) had superficial burns. The mean burns percentage in the patients was 19.3 ± 15.4%, the lowest was 2%, and the highest was 90%. The most common burns were caused by flame (42%) and boiling water (30.5%). The patients' outcomes revealed that 6% gained complete recovery, 86.5% partial recovery, 2.5% showed transplant rejection, and 5% died. Mean platelet levels in deceased patients had an upward trend. The mean platelet counts of patients were elevated during surgery (289,855 ± 165,378), decreased three days after surgery (282,778 ± 317,310), and elevated again five days after surgery (330,375 ± 208,571). However, no significant difference was found between the mean platelet counts during surgery, the third and fifth days after surgery in patients undergoing skin grafts (P = 0.057).
Conclusions: This study suggests that skin graft positively increases the patient's platelets. Further studies are needed to confirm the findings and elucidate the mechanism. Iranian Registry of Clinical Trial approval code (IRCT# IRCT20131112015390N8 & 06/01/2024).
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Autologous transplant; Iran; Platelet count; Skin graft; Surgery
تواريخ الأحداث: Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240711
رمز التحديث: 20240711
مُعرف محوري في PubMed: PMC11220946
DOI: 10.1186/s12893-024-02489-x
PMID: 38956520
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2482
DOI:10.1186/s12893-024-02489-x