Microbial allies: exploring fungal endophytes for biosynthesis of terpenoid indole alkaloids.

التفاصيل البيبلوغرافية
العنوان:	Microbial allies: exploring fungal endophytes for biosynthesis of terpenoid indole alkaloids.
المؤلفون:	Khalkho JP; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India., Beck A; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India., Priyanka; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India., Panda B; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India., Chandra R; Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India. rameshchandra@bitmesra.ac.in.
المصدر:	Archives of microbiology [Arch Microbiol] 2024 Jul 03; Vol. 206 (8), pp. 340. Date of Electronic Publication: 2024 Jul 03.
نوع المنشور:	Journal Article; Review
اللغة:	English
بيانات الدورية:	Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH:	Endophytes/metabolism , Endophytes/genetics , Fungi/metabolism , Fungi/genetics , Secologanin Tryptamine Alkaloids*/metabolism, Bacteria/metabolism ; Bacteria/genetics ; Bacteria/classification ; Biosynthetic Pathways ; Plants, Medicinal/microbiology ; Plants, Medicinal/metabolism ; Biological Products/metabolism
مستخلص:	Terpenoid indole alkaloids (TIAs) are natural compounds found in medicinal plants that exhibit various therapeutic activities, such as antimicrobial, anti-inflammatory, antioxidant, anti-diabetic, anti-helminthic, and anti-tumor properties. However, the production of these alkaloids in plants is limited, and there is a high demand for them due to the increasing incidence of cancer cases. To address this research gap, researchers have focused on optimizing culture media, eliciting metabolic pathways, overexpressing genes, and searching for potential sources of TIAs in organisms other than plants. The insufficient number of essential genes and enzymes in the biosynthesis pathway is the reason behind the limited production of TIAs. As the field of natural product discovery from biological species continues to grow, endophytes are being investigated more and more as potential sources of bioactive metabolites with a variety of chemical structures. Endophytes are microorganisms (fungi, bacteria, archaea, and actinomycetes), that exert a significant influence on the metabolic pathways of both the host plants and the endophytic cells. Bio-prospection of fungal endophytes has shown the discovery of novel, high-value bioactive compounds of commercial significance. The discovery of therapeutically significant secondary metabolites has been made easier by endophytic entities' abundant but understudied diversity. It has been observed that fungal endophytes have better intermediate processing ability due to cellular compartmentation. This paper focuses on fungal endophytes and their metabolic ability to produce complex TIAs, recent advancements in this area, and addressing the limitations and future perspectives related to TIA production. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة:	Award No. 202021-NFST-JHA-03517 National Fellowship and Scholarship for the Higher Education of ST Students (NFST); Award No. 202223-NFST-JHA-00832 National Fellowship and Scholarship for the Higher Education of ST Students (NFST)
فهرسة مساهمة:	Keywords: Bioactive compounds; Cancer drugs; Endophytes; Terpenoid indole alkaloids
المشرفين على المادة:	0 (Secologanin Tryptamine Alkaloids) 0 (Biological Products)
تواريخ الأحداث:	Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240814
رمز التحديث:	20240814
DOI:	10.1007/s00203-024-04067-4
PMID:	38960981
قاعدة البيانات:	MEDLINE

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تدمد:	1432-072X
DOI:	10.1007/s00203-024-04067-4