دورية أكاديمية
Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept.
| العنوان: | Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept. |
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| المؤلفون: | Tang SJ; School of Medicine, University of California Davis Medical Center, Sacramento, California, USA., Holle J; Cingulum Health, Sydney, Australia., Dadario NB; Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, USA., Ryan M; Cingulum Health, Sydney, Australia., Lesslar O; Cingulum Health, Sydney, Australia., Teo C; Cingulum Health, Sydney, Australia., Sughrue M; Cingulum Health, Sydney, Australia., Yeung J; Cingulum Health, Sydney, Australia.; Department of Neurosurgery, Yale University School of Medicine institution, New Haven, Connecticut, USA. |
| المصدر: | Brain injury [Brain Inj] 2024 Jul 04, pp. 1-11. Date of Electronic Publication: 2024 Jul 04. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8710358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-301X (Electronic) Linking ISSN: 02699052 NLM ISO Abbreviation: Brain Inj Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London ; New York : Taylor & Francis, c1987- |
| مستخلص: | Objective: To determine the safety and proof of concept of a parcel-guided, repetitive Transcranial Magnetic Stimulation (rTMS) in patients who develop a heterogeneous array of symptoms, known collectively as post-concussive syndrome (PCS), following traumatic brain injury (TBI). Methods: We performed a retrospective review of off-label, individualized, parcel-guided rTMS in 19 patients from December 2020 to May 2023. Patients had at least one instance of mild, moderate, or severe TBI and developed symptoms not present prior to injury. rTMS targets were identified based on machine learning connectomic software using functional connectivity anomaly matrices compared to healthy controls. EuroQol (EQ-5D), as a measurement of quality of life, and additional questionnaires dependent on individual's symptoms were submitted prior to, after, and during follow-up from rTMS. Results: Nineteen patients showed improvement in EQ-5D and Rivermead Post Concussion Symptoms Questionnaires - 3 after treatment and follow-up. For nine patients who developed depression, five (55%) attained response and remission based on the Beck Depression Inventory after treatment. Eight of ten patients with anxiety had a clinically significant reduction in Generalized Anxiety Disorder-7 scores during follow-up. Conclusion: Parcel-guided rTMS is safe and may be effective in reducing PCS symptoms following TBI and should incite further controlled studies. |
| فهرسة مساهمة: | Keywords: Individualized; connectomics; functional MRI; post-concussive disorder; rTMS |
| تواريخ الأحداث: | Date Created: 20240705 Latest Revision: 20240705 |
| رمز التحديث: | 20240705 |
| DOI: | 10.1080/02699052.2024.2371975 |
| PMID: | 38965876 |
| قاعدة البيانات: | MEDLINE |
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