دورية أكاديمية
The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology.
| العنوان: | The Impact of Early Life Adversity on Peripubertal Accelerated Epigenetic Aging and Psychopathology. |
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| المؤلفون: | Hogan CM; University of Massachusetts Amherst, Amherst, Massachusetts. Electronic address: cmhogan@umass.edu., Merrill SM; Warren Alpert Medical School at Brown University, Providence, Rhode Island., Hernandez Valencia E; University of Rhode Island, Kingston, Rhode Island., McHayle AA; Warren Alpert Medical School at Brown University, Providence, Rhode Island., Sisitsky MD; Florida International University, Miami, Florida., McDermott JM; University of Massachusetts Amherst, Amherst, Massachusetts., Parent J; Warren Alpert Medical School at Brown University, Providence, Rhode Island; University of Rhode Island, Kingston, Rhode Island; Emma Pendleton Bradley Hospital, East Providence, Rhode Island. |
| المصدر: | Journal of the American Academy of Child and Adolescent Psychiatry [J Am Acad Child Adolesc Psychiatry] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8704565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-5418 (Electronic) Linking ISSN: 08908567 NLM ISO Abbreviation: J Am Acad Child Adolesc Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2010- : New York : Elsevier Original Publication: [Baltimore, Md.] : The Academy, [1987- |
| مستخلص: | Objective: To examine longitudinal associations between early life threat and deprivation on epigenetic age acceleration at ages 9 and 15 years, and to examine associations of age acceleration on later internalizing and externalizing symptoms. Method: The study examines a large (n = 2,039) and racially diverse (Black/African American = 44%, Latino = 18%, White = 5%) sample from a national dataset. Epigenetic age acceleration was estimated using the pediatric buccal epigenetic clock. Early life threat and deprivation were measured using composites from the Parent-Child Conflict Tactics Scale and county-level violent and property crime rate data. Internalizing and externalizing symptoms came from parent-reported Child Behavior Checklist. Path analysis models examined associations of threat and deprivation at age 3 years on epigenetic age acceleration at ages 9 and 15. Experiences of threat were further broken down into threat experienced in the home and in the community. Results: Home threat experienced at age 3 years predicted age acceleration at 9 and 15, and community threat experienced at 3 predicted age acceleration at 15, but not at 9. Deprivation was not a significant predictor of accelerated aging. Age acceleration at age 9 predicted externalizing, but not internalizing, symptoms at age 15. Community threat had a direct effect on externalizing. No association emerged with internalizing. Conclusion: Findings revealed that threat, not deprivation, was predictive of age acceleration, demonstrating support for this pattern longitudinally, using an epigenetic clock that is accurate in children. The findings provide critical nuance to the examination of threat, and highlight associated risks and possible intervention points for externalizing symptoms. (Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: deprivation; externalizing; internalizing; pediatric buccal epigenetic clock; threat |
| تواريخ الأحداث: | Date Created: 20240705 Latest Revision: 20240805 |
| رمز التحديث: | 20240805 |
| DOI: | 10.1016/j.jaac.2024.04.019 |
| PMID: | 38969335 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1527-5418 |
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| DOI: | 10.1016/j.jaac.2024.04.019 |