دورية أكاديمية
أعرض في EDS

Hydroxytyrosol permeability comparisons and strategies to improve hydroxytyrosol stability in formulations.

التفاصيل البيبلوغرافية
العنوان: Hydroxytyrosol permeability comparisons and strategies to improve hydroxytyrosol stability in formulations.
المؤلفون: Feng M; Beijing Qingyan Boshi Health Management Co. Ltd., China., Li Y; Beijing Qingyan Boshi Health Management Co. Ltd., China., Jiang Y; Beijing Qingyan Boshi Health Management Co. Ltd., China. Electronic address: jiangjun@mail.fivedoctors.cn., Zhao C; Beijing Qingyan Boshi Health Management Co. Ltd., China. Electronic address: zhaochunyue@mail.fivedoctors.cn.
المصدر: International journal of pharmaceutics [Int J Pharm] 2024 Aug 15; Vol. 661, pp. 124434. Date of Electronic Publication: 2024 Jul 06.
نوع المنشور: Journal Article; Comparative Study
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Phenylethyl Alcohol*/analogs & derivatives , Phenylethyl Alcohol*/chemistry , Phenylethyl Alcohol*/pharmacokinetics , Phenylethyl Alcohol*/administration & dosage , Skin Absorption*/drug effects , Permeability* , Antioxidants*/chemistry , Antioxidants*/administration & dosage , Antioxidants*/pharmacokinetics , Drug Stability*, Animals ; Swine ; Skin/metabolism ; Hydrogels/chemistry ; Administration, Cutaneous ; Swine, Miniature ; Skin Cream/chemistry ; Chemistry, Pharmaceutical/methods ; Chromatography, High Pressure Liquid ; Ascorbic Acid/chemistry
مستخلص: There has been a growing interest in hydroxytyrosol (HT) due to its powerful antioxidant and free-radical scavenging properties when added to formulations such as pharmaceuticals and cosmetics. To study the stability and transdermal properties of hydrogels and creams (HT-based formulations), a high-performance liquid chromatography method was developed for determining HT. In the Franz diffusion cell system, both hydrogel and cream show a rapid and similar penetration profile through the Bama miniature pig skin. However, the Strat-M® membrane exhibits slightly lower permeability and is selective to different formulations; that is, the cream has a permeability value of 10.69%, while the hydrogel has a value of 5.27%. The dynamics parameters from the permeation assays indicate that the model using the Strat-M® membrane can be used as a screening tool to evaluate the skin uptake and permeation efficacy of different formulations. Adding 3-O-ethyl-L-ascorbic acid to HT-based formulations can effectively prevent discoloration under prolonged high-temperature storage, while combining multiple antioxidants delays degradation most effectively. This study provides novel ideas for functional formulation optimization to enhance the realism and reproducibility of cosmetic products containing HT and provides scientific evidence for the production, packaging, shelf life, storage, and transportation of products.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: HPLC analysis; Hydroxytyrosol; Stability studies; Transdermal absorption
المشرفين على المادة: ML9LGA7468 (Phenylethyl Alcohol)
10597-60-1 (3,4-dihydroxyphenylethanol)
0 (Antioxidants)
0 (Hydrogels)
PQ6CK8PD0R (Ascorbic Acid)
تواريخ الأحداث: Date Created: 20240707 Date Completed: 20240731 Latest Revision: 20240731
رمز التحديث: 20240801
DOI: 10.1016/j.ijpharm.2024.124434
PMID: 38972523
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3476
DOI:10.1016/j.ijpharm.2024.124434