دورية أكاديمية
[Advances in glucocorticoid resistance in otorhinolaryngological diseases].
| العنوان: | [Advances in glucocorticoid resistance in otorhinolaryngological diseases]. |
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| المؤلفون: | Li Y; Department of Otorhinolaryngology，Head and Neck Surgery，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University，Nanjing，210008，China., She W; Department of Otorhinolaryngology，Head and Neck Surgery，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University，Nanjing，210008，China. |
| المصدر: | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2024 Jul; Vol. 38 (7), pp. 661-665. |
| نوع المنشور: | Journal Article; Review; English Abstract |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu Country of Publication: China NLM ID: 101303164 Publication Model: Print Cited Medium: Print ISSN: 2096-7993 (Print) Linking ISSN: 20967993 NLM ISO Abbreviation: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wuhan Shi : Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu |
| مواضيع طبية MeSH: | Glucocorticoids*/therapeutic use , Otorhinolaryngologic Diseases*/drug therapy , Drug Resistance* , Receptors, Glucocorticoid*/metabolism, Humans ; Meniere Disease/drug therapy |
| مستخلص: | Glucocorticoids（GC） are widely used in the clinical treatment of autoimmune inner ear diseases, sudden sensorineural hearing loss, Meniere's disease, sinusitis and other otolaryngology diseases. However, GC resistance remains a major factor contributing to the poor efficacy of clinical treatments. The mechanism of GC resistance is still unclear. This paper reviews the related mechanisms of GC resistance from the perspectives of GC receptor factors and non-GC receptor factors. Additionally, it summarizes the latest research progress on GC resistance in otolaryngological diseases, with the aim of identifying effective clinical alternative treatment options for reversing GC resistance in the future. Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.) |
| فهرسة مساهمة: | Keywords: glucocorticoid resistance; glucocorticoids; receptor; sinusitis; sudden sensorineural hearing loss Local Abstract: [Publisher, Chinese] 摘要: 糖皮质激素（glucocorticoids，GC）临床上广泛应用于自身免疫性内耳病、突发性聋、梅尼埃病及鼻窦炎等耳鼻咽喉疾病的治疗，部分患者存在GC抵抗现象，但导致GC抵抗因素机制尚不清楚，本文从GC受体因素和非GC受体因素两方面阐述了GC抵抗的相关机制，并综述其在耳鼻咽喉科疾病的最新研究进展，旨在未来寻找GC抵抗生物标志物，提高GC疗效提出新策略。. |
| المشرفين على المادة: | 0 (Glucocorticoids) 0 (Receptors, Glucocorticoid) |
| تواريخ الأحداث: | Date Created: 20240708 Date Completed: 20240708 Latest Revision: 20240708 |
| رمز التحديث: | 20240708 |
| DOI: | 10.13201/j.issn.2096-7993.2024.07.020 |
| PMID: | 38973050 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2096-7993 |
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| DOI: | 10.13201/j.issn.2096-7993.2024.07.020 |