دورية أكاديمية
Design, synthesis and biological evaluation of piperine derivatives as potent antitumor agents.
| العنوان: | Design, synthesis and biological evaluation of piperine derivatives as potent antitumor agents. |
|---|---|
| المؤلفون: | Wang XJ; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China. Electronic address: wangxiujun@jou.edu.cn., Qiao Y; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Wang XS; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Zhang SY; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Li HX; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Hao HH; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Li KQ; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Ma SJ; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Zhu QJ; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China., Ji J; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China. Electronic address: jijing@jou.edu.cn., Liu B; College of Pharmacy, Jiangsu Ocean University, Lianyungang 222000, China. Electronic address: liubin@jou.edu.cn. |
| المصدر: | Fitoterapia [Fitoterapia] 2024 Sep; Vol. 177, pp. 106118. Date of Electronic Publication: 2024 Jul 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Piperidines*/pharmacology , Piperidines*/chemical synthesis , Piperidines*/chemistry , Benzodioxoles*/pharmacology , Benzodioxoles*/chemical synthesis , Polyunsaturated Alkamides*/pharmacology , Polyunsaturated Alkamides*/chemical synthesis , Polyunsaturated Alkamides*/chemistry , Alkaloids*/pharmacology , Alkaloids*/chemical synthesis , Alkaloids*/chemistry, Humans ; Animals ; Molecular Structure ; Cell Line, Tumor ; HeLa Cells ; Chick Embryo ; Cell Movement/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Drug Design ; Cell Proliferation/drug effects |
| مستخلص: | A series of piperine derivatives were designed and successfully synthesized. The antitumor activities of these compounds against 293 T human normal cells, as well as MDA-MB-231 (breast) and Hela (cervical) cancer cell lines, were assessed through the MTT assay. Notably, compound H7 exhibited moderate activity, displaying reduced toxicity towards non-tumor 293 T cells while potently enhancing the antiproliferative effects in Hela and MDA-MB-231 cells. The IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antitumor activity; Chicken embryo model; Piperine derivatives |
| المشرفين على المادة: | 0 (Piperidines) 0 (Benzodioxoles) U71XL721QK (piperine) 0 (Polyunsaturated Alkamides) 0 (Alkaloids) 0 (Antineoplastic Agents, Phytogenic) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20240708 Date Completed: 20240809 Latest Revision: 20240809 |
| رمز التحديث: | 20240812 |
| DOI: | 10.1016/j.fitote.2024.106118 |
| PMID: | 38977252 |
| قاعدة البيانات: | MEDLINE |
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