دورية أكاديمية
[Association between maternal peri-conceptional exposures and risk of hypospadias and cryptorchidism in offspring].
| العنوان: | [Association between maternal peri-conceptional exposures and risk of hypospadias and cryptorchidism in offspring]. |
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| المؤلفون: | Xie SH; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Yue WT; Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Zhang EJ; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Gao S; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Su SF; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Hao YX; School of Public Health, Capital Medical University, Beijing 100069, China., Zhang Y; Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Liu JH; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Yin CH; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China., Liu RX; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China. |
| المصدر: | Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2024 Jul 09; Vol. 104 (26), pp. 2424-2430. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhonghua yi xue hui Original Publication: Beijing : Zhonghua yi xue hui. |
| مواضيع طبية MeSH: | Hypospadias*/etiology , Hypospadias*/epidemiology , Cryptorchidism*/etiology , Cryptorchidism*/epidemiology , Maternal Exposure*/adverse effects, Humans ; Female ; Male ; Pregnancy ; Adult ; Risk Factors ; China/epidemiology ; Infant, Newborn ; Birth Cohort ; Logistic Models ; Prenatal Exposure Delayed Effects/etiology ; Surveys and Questionnaires |
| مستخلص: | Objective: To investigate the relationship between maternal exposures to peri-conceptional risk factors and the risk of hypospadias and cryptorchidism in offspring. Methods: Pregnant women who delivered male newborns and participated in the China birth cohort study between February 2018 and December 2020 at the research center of Beijing Obstetrics and Gynecology Hospital, Capital Medical University were selected for the study. All were enrolled at 6-13 +6 weeks of their gestation. Baseline risk factor information was collected by questionnaire survey. Information on the outcome of hypospadias and cryptorchidism was obtained by clinical examination at birth and ultrasonography. Logistic regression was used to analyze the Odds Ratio ( OR ) and 95% Confidence Interval (95% CI ) of each factor with respect to the onset of the outcome. Results: A total of 15, 833 pregnant women with an average age of (31.81±3.84) years were included. Among their offsprings, 113 were diagnosed as hypospadias or cryptorchidism (42 hypospadias, 69 cryptorchidism, and 2 both hypospadias and crypterchidism), with an incidence of 7.14‰. The results of multivariate logistic regression analysis showed that mothers with pregnancy history of birth defects ( OR= 3.01, 95% CI : 1.09-8.35), with preconception Hepatitis B infection ( OR =4.74, 95% CI: 1.10-20.42), fetal growth restriction ( OR =4.02, 95% CI : 2.10-7.68), multivitamin use since preconception ( OR= 1.98, 95% CI : 1.12-3.52), and never cook and eat at home ( OR =2.17, 95% CI : 1.23-3.82) were risk factors for hypospadias and cryptorchidism (all P <0.05). Conclusions: Obesity in early pregnancy, preconception Hepatitis B infection, pregnancy history of birth defects, fetal growth restriction, multivitamin use before pregnancy, and rarely cook and eat at home were associated with an increased risk of hypospadias or cryptorchidism in their offsprings. |
| معلومات مُعتمدة: | 2024-2G-2118 Capital's Funds for Health Improvement and Research; 2022-1-003 Leading Talents in the Construction Project of High Level Public Health Technical Talents in Beijing; QML20231402 Youth Program of Beijing Hospitals Authority; 2016YFC1000101 National Key Research and Development Program of China; BYESS2022200 Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology; FCYY202102 Special project for young and middle-aged research backbone supported by Beijing Obstetrics and Gynecology Hospital |
| فهرسة مساهمة: | Local Abstract: [Publisher, Chinese] 目的： 探讨孕妇围孕期风险因素暴露与子代尿道下裂或隐睾发生的关联。 方法： 前瞻性选取2018年2月至2020年12月在首都医科大学附属北京妇产医院研究中心参加“中国出生人口队列”研究且分娩男性新生儿的孕妇为研究对象。所有研究对象于孕6~13 +6 周入组，采用问卷调查收集围孕期危险因素信息，通过超声检查和出生时临床查体获取尿道下裂或隐睾结局信息。采用多因素logistic回归模型分析发生尿道下裂或隐睾的相关因素。 结果： 共纳入15 833例孕妇，年龄为（31.81±3.84）岁，其子代诊断为尿道下裂或隐睾为113例（尿道下裂42例，隐睾69例，尿道下裂及隐睾2例），发生率为7.14‰。多因素logistic回归分析结果显示，既往出生缺陷孕育史（ OR= 3.01，95% CI ：1.09~8.35）、孕前患乙型肝炎（ OR= 4.74，95% CI ：1.10~20.42）、胎儿生长受限（ OR =4.02，95% CI ：2.10~7.68）、孕前开始服用复合维生素（ OR= 1.98，95% CI ：1.12~3.52）和很少在家烹饪（ OR= 2.17，95% CI ：1.23~3.82）是子代发生尿道下裂或隐睾的相关因素（均 P <0.05）。 结论： 孕妇围孕期BMI≥28 kg/m 2 、患乙型肝炎、既往出生缺陷孕育史、胎儿生长受限、孕前开始服用复合维生素和很少在家烹饪与子代尿道下裂或隐睾发生相关。. |
| تواريخ الأحداث: | Date Created: 20240709 Date Completed: 20240709 Latest Revision: 20240709 |
| رمز التحديث: | 20240709 |
| DOI: | 10.3760/cma.j.cn112137-20231215-01387 |
| PMID: | 38978366 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0376-2491 |
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| DOI: | 10.3760/cma.j.cn112137-20231215-01387 |