دورية أكاديمية
[Association between early pregnancy maternal blood pressure and risk of congenital heart disease in offspring].
| العنوان: | [Association between early pregnancy maternal blood pressure and risk of congenital heart disease in offspring]. |
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| المؤلفون: | Zhang EJ; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Liu RX; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Yue WT; Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Gao S; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Su SF; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Zhu HP; School of Public Health, Capital Medical University, Beijing 100069, China., Liu JH; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Xie SH; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Zhang Y; Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China., Yin CH; Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China. |
| المصدر: | Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2024 Jul 09; Vol. 104 (26), pp. 2431-2437. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhonghua yi xue hui Original Publication: Beijing : Zhonghua yi xue hui. |
| مواضيع طبية MeSH: | Heart Defects, Congenital* , Blood Pressure*, Humans ; Female ; Pregnancy ; Adult ; China/epidemiology ; Risk Factors ; Pregnancy Trimester, First ; Cohort Studies ; Logistic Models |
| مستخلص: | Objective: To analyze the association between maternal blood pressure and congenital heart disease (CHD) in offspring. Methods: From February 2018 to December 2020, pregnant women who participated in the China birth cohort study in Beijing Obstetrics and Gynecology Hospital, Shenzhen Maternal and Child Healthcare Hospital and Chengdu Women's and Children's Central Hospital were enrolled in this study. The baseline and follow-up information were collected using an electronic data collection system. Stepwise logistic regression model was used to analyze the association between maternal blood pressure including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure difference (PP) in the first trimester of pregnancy and the risk of CHD in the offspring. A restrictive cubic spline curve was used to draw the dose-response curve between maternal blood pressure and CHD. Results: A total of 55 552 participants were included in this study. Of them, 31 038, 15 375 and 9 139 pregnant women were enrolled in Beijing Obstetrics and Gynecology Hospital, Shenzhen Maternal & Child Healthcare Hospital and Chendu Women's and Children's Central Hospital, respecitively. The age of pregnant women was (31.3±4.0) and the incidence of CHD in the offspring was 0.78% (435/55 552) . Multivariable logistic regression model analysis showed that the increase of SBP ( OR =1.01, 95% CI : 1.00-1.02), DBP ( OR =1.01, 95% CI : 1.00-1.03) and MAP ( OR =1.02, 95% CI : 1.00-1.03) in the first trimester were significantly associated with the risk of CHD in the offspring. The restrictive cubic spline analysis showed a positive linear association of SBP ( P |
| معلومات مُعتمدة: | 2016YFC1000101 National Key Research and Development Program of China; 82304088 National Natural Science Foundation of China; 2022-1-003 Leading Talents in the Construction Project of High Level Public Health Technical Talents in Beijing; QML20231407 Beijing Hospitals Authority Youth Programme; 2022-2G-2119 The Fund for Beijing Science and Technology Development of TCM |
| فهرسة مساهمة: | Local Abstract: [Publisher, Chinese] 目的： 分析孕妇孕早期血压与子代先天性心脏病（CHD）发生风险的关联。 方法： 本研究为前瞻性队列研究，选择2018年2月至2020年12月在首都医科大学附属北京妇产医院、深圳市妇幼保健院及成都市妇女儿童中心医院参加“中国出生人口队列”研究的孕妇作为研究对象。采用电子数据采集系统收集基线和随访信息。采用logistic逐步回归模型，分析孕妇孕早期血压相关指标（收缩压、舒张压、平均动脉压以及脉压）与子代CHD发生风险的关联。采用限制性立方样条曲线，分析孕妇孕早期血压与子代CHD发生风险的剂量反应关系。 结果： 共纳入研究对象55 552名，首都医科大学附属北京妇产医院、深圳市妇幼保健院及成都市妇女儿童中心医院分别纳入31 038、15 375及9 139名；所有孕妇年龄为（31.3±4.0）岁，子代CHD发生率为0.78%（435例）。多因素logistic回归模型分析结果显示，孕妇孕早期较高的收缩压（ OR= 1.01，95% CI ：1.00~1.02）、舒张压（ OR= 1.01，95% CI ：1.00~1.03）、平均动脉压（ OR= 1.02，95% CI ：1.00~1.03）均与子代发生CHD相关（均 P <0.05）。限制性立方样条分析显示，孕早期收缩压（ P |
| تواريخ الأحداث: | Date Created: 20240709 Date Completed: 20240709 Latest Revision: 20240709 |
| رمز التحديث: | 20240709 |
| DOI: | 10.3760/cma.j.cn112137-20231209-01328 |
| PMID: | 38978367 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0376-2491 |
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| DOI: | 10.3760/cma.j.cn112137-20231209-01328 |