دورية أكاديمية
أعرض في EDS

Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet's disease uveitis.

التفاصيل البيبلوغرافية
العنوان: Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet's disease uveitis.
المؤلفون: Qin W; Department of Anesthesiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266071, China.; Beijing Key Laboratory of Gene Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing100875, China., Liang A; Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.; Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China., Han X; Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China., Zhang M; Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China., Gao Y; Beijing Key Laboratory of Gene Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing100875, China. gaoyouhe@bnu.edu.cn., Zhao C; Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. zhaochan@pumch.cn.
المصدر: BMC ophthalmology [BMC Ophthalmol] 2024 Jul 09; Vol. 24 (1), pp. 277. Date of Electronic Publication: 2024 Jul 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967802 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2415 (Electronic) Linking ISSN: 14712415 NLM ISO Abbreviation: BMC Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Behcet Syndrome*/urine , Behcet Syndrome*/diagnosis , Behcet Syndrome*/metabolism , Biomarkers*/urine , Uveitis*/urine , Uveitis*/diagnosis , Uveitis*/metabolism , Proteome*/analysis , Proteome*/metabolism , Proteomics*/methods, Humans ; Male ; Female ; Adult ; Middle Aged ; Tandem Mass Spectrometry
مستخلص: Purpose: Behçet's disease-associated uveitis (BDU) is a severe, recurrent inflammatory condition affecting the eye and is part of a systemic vasculitis with unknown etiology, making biomarker discovery essential for disease management. In this study, we intend to investigate potential urinary biomarkers to monitor the disease activity of BDU.
Methods: Firstly, label-free data-dependent acquisition (DDA) and tandem mass tag (TMT)-labeled quantitative proteomics methods were used to profile the proteomes of urine from active and quiescent BDU patients, respectively. For further exploration, the remaining fifty urine samples were analyzed by a data-independent acquisition (DIA) quantitative proteomics method.
Results: Twenty-nine and 21 differential proteins were identified in the same urine from BDU patients by label-free DDA and TMT-labeled analyses, respectively. Seventy-nine differentially expressed proteins (DEPs) were significantly changed in other active BDU urine samples compared to those in quiescent BDU urine samples by IDA analysis. Gene Ontology (GO) and protein-protein interaction (PPI) analyses revealed that the DEPs were associated with multiple functions, including the immune and neutrophil activation responses. Finally, seven proteins were identified as candidate biomarkers for BDU monitoring and recurrence prediction, namely, CD38, KCRB, DPP4, FUCA2, MTPN, S100A8 and S100A9.
Conclusions: Our results showed that urine can be a good source of biomarkers for BDU. These dysregulated proteins provide potential urinary biomarkers for BDU activity monitoring and provide valuable clues for the analysis of the pathogenic mechanisms of BDU.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 82000881 National Natural Science Foundation of China; 7192174 Beijing Natural Science Foundation; 7192174 Beijing Natural Science Foundation; Z171100001017217 Clinical Research Fund of Beijing Municipal Science and Technology Commission
فهرسة مساهمة: Keywords: Behcet’s disease uveitis; Biomarkers; Data-independent acquisition; Tandem mass tags; Urine proteome
المشرفين على المادة: 0 (Biomarkers)
0 (Proteome)
تواريخ الأحداث: Date Created: 20240709 Date Completed: 20240710 Latest Revision: 20240712
رمز التحديث: 20240712
مُعرف محوري في PubMed: PMC11232131
DOI: 10.1186/s12886-024-03557-9
PMID: 38982370
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2415
DOI:10.1186/s12886-024-03557-9