دورية أكاديمية
أعرض في EDS

Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping.

التفاصيل البيبلوغرافية
العنوان: Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping.
المؤلفون: Boros GAB; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Hueb W; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil. whady.hueb@incor.usp.br.; Divisão Clínica - Instituto do Coração (InCor), Faculdade de Medicina, Hospital das Clínicas - HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar 44, AB 1, Sala 114, Cerqueira César, São Paulo, 05403-000, SP, Brazil. whady.hueb@incor.usp.br., Rezende PC; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Rochitte CE; Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Nomura CH; Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Lima EG; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., de Oliveira Laterza Ribeiro M; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Dallazen AR; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Garcia RMR; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Ramires JAF; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil., Kalil-Filho R; Department of Clinical Cardiology - Heart Institute (InCor), University of São Paulo, São Paulo, Brazil.
المصدر: Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2024 Jul 09; Vol. 16 (1), pp. 156. Date of Electronic Publication: 2024 Jul 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101488958 Publication Model: Electronic Cited Medium: Print ISSN: 1758-5996 (Print) Linking ISSN: 17585996 NLM ISO Abbreviation: Diabetol Metab Syndr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central
مستخلص: Background: This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping.
Methods: A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed.
Results: Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain.
Conclusions: CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals.
Trial Registration: http://www.controlled-trials.com/ISRCTN09454308.
(© 2024. The Author(s).)
References: Am J Cardiol. 1974 Jul;34(1):29-34. (PMID: 4835750)
J Cardiovasc Magn Reson. 2020 Mar 12;22(1):19. (PMID: 32160925)
JACC Heart Fail. 2015 Feb;3(2):136-45. (PMID: 25660838)
Cardiovasc Diabetol. 2023 Mar 31;22(1):78. (PMID: 37004049)
Mol Cell Biochem. 2014 Jan;386(1-2):233-49. (PMID: 24307101)
JACC Cardiovasc Imaging. 2021 Jun;14(6):1164-1173. (PMID: 33454272)
Eur Heart J Cardiovasc Imaging. 2018 Jun 1;19(6):701-708. (PMID: 28950340)
J Cardiovasc Magn Reson. 2016 Dec 12;18(1):92. (PMID: 27955698)
Radiology. 2012 Dec;265(3):724-32. (PMID: 23091172)
J Cardiovasc Magn Reson. 2013 Oct 14;15:92. (PMID: 24124732)
J Cardiovasc Magn Reson. 2019 Aug 8;21(1):46. (PMID: 31391036)
Circulation. 2016 Jun 14;133(24):2459-502. (PMID: 27297342)
J Cardiovasc Magn Reson. 2016 Aug 26;18(1):51. (PMID: 27561421)
Eur Radiol. 2022 Nov;32(11):7647-7656. (PMID: 35567605)
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):307-15. (PMID: 25246506)
J Cardiovasc Magn Reson. 2016 Nov 30;18(1):89. (PMID: 27899132)
JACC Cardiovasc Imaging. 2015 Dec;8(12):1444-1460. (PMID: 26699113)
Circulation. 2007 Jun 26;115(25):3213-23. (PMID: 17592090)
Diabetes. 2016 Jan;65(1):44-52. (PMID: 26438611)
Radiology. 2016 Mar;278(3):658-76. (PMID: 26885733)
Cardiovasc Diabetol. 2018 Jan 04;17(1):7. (PMID: 29301529)
Magn Reson Imaging. 2020 May;68:190-196. (PMID: 32084516)
Sci Rep. 2022 Dec 31;12(1):22644. (PMID: 36587037)
J Cardiovasc Magn Reson. 2020 Feb 24;22(1):17. (PMID: 32089132)
J Cardiovasc Magn Reson. 2015 Jun 11;17:48. (PMID: 26062931)
Circ Cardiovasc Imaging. 2012 Jan;5(1):51-9. (PMID: 22135399)
Eur Radiol. 2021 Jun;31(6):3962-3972. (PMID: 33277669)
Circulation. 2010 Jul 13;122(2):138-44. (PMID: 20585010)
Am J Cardiol. 2009 Nov 15;104(10):1398-401. (PMID: 19892057)
Eur Heart J. 2012 May;33(10):1268-78. (PMID: 22279111)
Magn Reson Med. 2004 Jul;52(1):141-6. (PMID: 15236377)
Ann Thorac Surg. 2016 Jun;101(6):2202-8. (PMID: 26912303)
Am J Med. 2008 Sep;121(9):748-57. (PMID: 18724960)
J Am Soc Echocardiogr. 2010 Dec;23(12):1266-72. (PMID: 20932716)
فهرسة مساهمة: Keywords: Cardiac magnetic resonance - feature tracking; Coronary artery disease; Extracellular volume; T1 mapping; Type 2 diabetes mellitus
تواريخ الأحداث: Date Created: 20240709 Latest Revision: 20240712
رمز التحديث: 20240712
مُعرف محوري في PubMed: PMC11232262
DOI: 10.1186/s13098-024-01395-9
PMID: 38982515
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا