دورية أكاديمية

Clinical features, severity, and immunological changes during venom immunotherapy in children and adults.

التفاصيل البيبلوغرافية
العنوان: Clinical features, severity, and immunological changes during venom immunotherapy in children and adults.
المؤلفون: Buyuktiryaki B; From the Division of Pediatric Allergy, School of Medicine, Department of Pediatrics, Koc University, Istanbul, Turkey., Hela F; Research Center for Translational Medicine, Graduate School of Health Sciences, Koc University, Istanbul, Turkey., Ozturk AB; Division of Allergy and Immunology, Department of Pulmonary Medicine, School of Medicine, Medeniyet University, Istanbul, Turkey., Dursun AB; Division of Allergy, and Immunology, Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey., Donmez H; Division of Allergy, and Immunology, Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize, Turkey., Gelincik A; Division of Immunology and Allergy Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Yegit OO; Division of Immunology and Allergy Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Yavuz ST; Department of Pediatric Allergy, Children's Hospital, University of Bonn, Bonn, Germany., Sahiner UM; Division of Allergy, Department of Pediatrics, School of Medicine, Hacettepe University, Ankara, Turkey., Albayrak O; Flow Cytometry Core Facility, Research Center for Translational Medicine, Istanbul, Turkey., Damadoglu E; Division of Allergy and Immunology, Department of Pulmonary Medicine, School of Medicine, Hacettepe University, Ankara, Turkey., Erdogan T; Division of Immunology and Allergy, Department of Internal Medicine, School of Medicine, Baskent University, Ankara, Turkey, and., Firtina S; Clinical Laboratory, American Hospital, Istanbul, Turkey., Taylan D; Clinical Laboratory, American Hospital, Istanbul, Turkey., Soyer O; Division of Allergy, Department of Pediatrics, School of Medicine, Hacettepe University, Ankara, Turkey., Karakaya G; Division of Allergy and Immunology, Department of Pulmonary Medicine, School of Medicine, Hacettepe University, Ankara, Turkey., Kalyoncu AF; Division of Allergy and Immunology, Department of Pulmonary Medicine, School of Medicine, Hacettepe University, Ankara, Turkey., Sekerel B; Division of Allergy, Department of Pediatrics, School of Medicine, Hacettepe University, Ankara, Turkey., Sackesen C; From the Division of Pediatric Allergy, School of Medicine, Department of Pediatrics, Koc University, Istanbul, Turkey.
المصدر: Allergy and asthma proceedings [Allergy Asthma Proc] 2024 Jul 01; Vol. 45 (4), pp. 276-283.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: OceanSide Publications Country of Publication: United States NLM ID: 9603640 Publication Model: Print Cited Medium: Internet ISSN: 1539-6304 (Electronic) Linking ISSN: 10885412 NLM ISO Abbreviation: Allergy Asthma Proc Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Providence, R.I. : OceanSide Publications, c1996-
مواضيع طبية MeSH: Desensitization, Immunologic*/methods , Immunoglobulin E*/blood , Immunoglobulin E*/immunology , Arthropod Venoms*/immunology, Humans ; Child ; Adult ; Male ; Female ; Adolescent ; Animals ; Middle Aged ; Young Adult ; Severity of Illness Index ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Hypersensitivity/therapy ; Hypersensitivity/immunology ; Hypersensitivity/diagnosis ; Insect Bites and Stings/immunology ; Insect Bites and Stings/therapy ; Child, Preschool ; Allergens/immunology ; Hymenoptera/immunology ; Prospective Studies ; Tryptases/blood ; Biomarkers
مستخلص: Background: Hymenoptera venom allergy (HVA) is among the most common causes of severe allergic reactions worldwide. Objective: To investigate clinical features and factors that affect the severity of HVA and to determine the alterations in immunologic biomarkers after venom immunotherapy (VIT). Methods: Seventy-six adults and 36 children were prospectively investigated. We analyzed specific immunoglobulin E (sIgE) and sIgG4 levels of venom extracts and components (rApi m1, rApi m10, rVes v1, rVes v5, rPol d5) before and after the first year of VIT. Results: Although cardiovascular symptoms were more common in adults (p < 0.001), the skin was the most affected organ in children (p = 0.009). Serum basal tryptase (sBT) levels were higher in the adults than the children (p < 0.001). The absence of urticaria (odds ratio [OR] 4.208 [95% confidence interval {CI}, 1.395-12.688]; p = 0.011) and sBT ≥ 5.2 ng/mL (OR 11.941 [95% CI, 5.220-39.733]; p < 0.001) were found as the risk factors for grade IV reactions. During VIT, changes in sIgE levels were variable. In the Apis VIT group, we observed remarkable increases in sIgG4 levels in Apis extract and rApi m1 but not in Api m10. Vespula extract, rVes v1, and rVes v5 sIgG4 levels were significantly increased in Vespula VIT group, we also detected significant increases in the Polistes extract and rPol d5 sIgG4 levels, which were not observed in the Apis VIT group. In the patients who received both Apis and Vespula VIT, increases in sIgG4 levels were observed for both venoms. Conclusion: Adults and children can have different clinical patterns. After 1 year, VIT induced a strong IgG4 response. Although Apis immunotherapy (IT) induced Apis sIgG4, excluding Api m10, Vespula IT induced both Vespula and Polistes sIgG4.
المشرفين على المادة: 37341-29-0 (Immunoglobulin E)
0 (Arthropod Venoms)
0 (Immunoglobulin G)
0 (Allergens)
EC 3.4.21.59 (Tryptases)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240710 Date Completed: 20240710 Latest Revision: 20240710
رمز التحديث: 20240710
DOI: 10.2500/aap.2024.45.240017
PMID: 38982596
قاعدة البيانات: MEDLINE
الوصف
تدمد:1539-6304
DOI:10.2500/aap.2024.45.240017