دورية أكاديمية
Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer.
| العنوان: | Helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer. |
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| المؤلفون: | Jin LX; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Fang YP; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Xia CM; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Cai TW; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Li QQ; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Wang YY; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Yan HF; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China., Chen X; Department of Gastroenterology, Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), Wenling 317500, Zhejiang Province, China. werla@sina.com. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2024 Jun 28; Vol. 30 (24), pp. 3076-3085. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Helicobacter Infections*/microbiology , Helicobacter pylori*/isolation & purification , Helicobacter pylori*/genetics , Duodenal Ulcer*/microbiology , Duodenal Ulcer*/diagnosis , Gastric Mucosa*/microbiology , Gastric Mucosa*/pathology , Gastrointestinal Microbiome* , Stomach Ulcer*/microbiology, Humans ; Male ; Female ; Middle Aged ; Adult ; Case-Control Studies ; Aged ; Metagenomics/methods ; Duodenum/microbiology ; Dysbiosis/microbiology |
| مستخلص: | Background: Helicobacter pylori (H. pylori) infection is closely associated with gastrointestinal diseases. Our preliminary studies have indicated that H. pylori infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer (GU) or duodenal ulcer (DU). Aim: To investigate the contributions of H . pylori infection and the mucosal microbiome to the pathogenesis and progression of ulcerative diseases. Methods: Patients with H . pylori infection and either GU or DU, and healthy individuals without H . pylori infection were included. Gastric or duodenal mucosal samples was obtained and subjected to metagenomic sequencing. The compositions of the microbial communities and their metabolic functions in the mucosal tissues were analyzed. Results: Compared with that in the healthy individuals, the gastric mucosal microbiota in the H . pylori -positive patients with GU was dominated by H . pylori , with significantly reduced biodiversity. The intergroup differential functions, which were enriched in the H . pylori -positive GU patients, were all derived from H . pylori , particularly those concerning transfer RNA queuosine-modification and the synthesis of demethylmenaquinones or menaquinones. A significant enrichment of the uibE gene was detected in the synthesis pathway. There was no significant difference in microbial diversity between the H. pylori -positive DU patients and healthy controls. Conclusion: H . pylori infection significantly alters the gastric microbiota structure, diversity, and biological functions, which may be important contributing factors for GU. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Duodenal ulcer; Gastric ulcer; Helicobacter pylori; Menaquinones; Metagenomic sequencing; Transfer RNA queuosine-modification |
| تواريخ الأحداث: | Date Created: 20240710 Date Completed: 20240710 Latest Revision: 20240711 |
| رمز التحديث: | 20240711 |
| مُعرف محوري في PubMed: | PMC11230059 |
| DOI: | 10.3748/wjg.v30.i24.3076 |
| PMID: | 38983956 |
| قاعدة البيانات: | MEDLINE |
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