دورية أكاديمية
Differential regulation of mitochondrial uncoupling protein 2 in cancer cells.
| العنوان: | Differential regulation of mitochondrial uncoupling protein 2 in cancer cells. |
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| المؤلفون: | Beikbaghban T; Physiology and Biophysics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria., Proietti L; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria., Ebner J; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria., Sango R; Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria; Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria; Doctoral School in Microbiology and Environmental Science, University of Vienna, Vienna, Austria., Rattei T; Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria., Weichhart T; Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Austria., Grebien F; Institute for Medical Biochemistry, University of Veterinary Medicine, Vienna, Austria; St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Sternberg F; Physiology and Biophysics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria; Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Austria. Electronic address: felix.sternberg@univie.ac.at., Pohl EE; Physiology and Biophysics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria. Electronic address: elena.pohl@vetmeduni.ac.at. |
| المصدر: | Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2024 Nov 01; Vol. 1865 (4), pp. 149486. Date of Electronic Publication: 2024 Jul 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2650 (Electronic) Linking ISSN: 00052728 NLM ISO Abbreviation: Biochim Biophys Acta Bioenerg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Uncoupling Protein 2*/metabolism , Uncoupling Protein 2*/genetics , Neoplasms*/metabolism , Neoplasms*/pathology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Mitochondria/metabolism ; Cell Proliferation ; Cell Hypoxia |
| مستخلص: | The persistent growth of cancer cells is underscored by complex metabolic reprogramming, with mitochondria playing a key role in the transition to aerobic glycolysis and representing new therapeutic targets. Mitochondrial uncoupling protein 2 (UCP2) has attracted interest because of its abundance in rapidly proliferating cells, including cancer cells, and its involvement in cellular metabolism. However, the specific contributions of UCP2 to cancer biology remain poorly defined. Our investigation of UCP2 expression in various human and mouse cancer cell lines aimed to elucidate its links to metabolic states, proliferation, and adaptation to environmental stresses such as hypoxia and nutrient deprivation. We observed significant variability in UCP2 expression across cancer types, with no direct correlation to their metabolic activity or proliferation rates. UCP2 abundance was also differentially affected by nutrient availability in different cancer cells, but UCP2 was generally downregulated under hypoxia. These findings challenge the notion that UCP2 is a marker of malignant potential and suggest its more complex involvement in the metabolic landscape of cancer. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Citric acid cycle; Extracellular acidification rate; Metabolite transport; Oxygen consumption rate; Pyruvate kinase; Uncouplers; Warburg effect |
| المشرفين على المادة: | 0 (Uncoupling Protein 2) 0 (UCP2 protein, human) 0 (Ucp2 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20240710 Date Completed: 20240906 Latest Revision: 20240916 |
| رمز التحديث: | 20240917 |
| DOI: | 10.1016/j.bbabio.2024.149486 |
| PMID: | 38986826 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-2650 |
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| DOI: | 10.1016/j.bbabio.2024.149486 |