Preliminary evidence for therapeutic impact of intravesical glucosamine on protamine sulfate and potassium chloride-induced bladder overactivity in rat model.

التفاصيل البيبلوغرافية
العنوان:	Preliminary evidence for therapeutic impact of intravesical glucosamine on protamine sulfate and potassium chloride-induced bladder overactivity in rat model.
المؤلفون:	Lu SH; Department of Urology, Taipei Medical University Hospital, No. 252, Wu-Xing Street, Taipei, 11031, Taiwan. shlu77777@gmail.com.; School of Medicine, Department of Urology, Taipei Medical University, Taipei, Taiwan. shlu77777@gmail.com.; Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan. shlu77777@gmail.com., Yun TF; Department of Urology, Taipei Medical University Hospital, No. 252, Wu-Xing Street, Taipei, 11031, Taiwan.; School of Medicine, Department of Urology, Taipei Medical University, Taipei, Taiwan., Kou YR; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Chang YP; Department of Healthcare Information and Management, Ming Chuan University, Taoyuan, Taiwan. ypchangtyvh@gmail.com.; Division of Nephrology, Taoyuan Branch, Taipei Veterans General Hospital, Taoyuan, Taiwan. ypchangtyvh@gmail.com.
المصدر:	World journal of urology [World J Urol] 2024 Jul 11; Vol. 42 (1), pp. 405. Date of Electronic Publication: 2024 Jul 11.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer International Country of Publication: Germany NLM ID: 8307716 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-8726 (Electronic) Linking ISSN: 07244983 NLM ISO Abbreviation: World J Urol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [Berlin ; New York] : Springer International, 1983-
مواضيع طبية MeSH:	Urinary Bladder, Overactive/drug therapy , Rats, Sprague-Dawley , Protamines* , Disease Models, Animal* , Potassium Chloride* , Glucosamine/pharmacology , Glucosamine/therapeutic use , Glucosamine*/administration & dosage, Animals ; Female ; Rats ; Administration, Intravesical
مستخلص:	Purpose: To investigate the protective effect of intravesical glucosamine in treating overactive bladder (OAB). Methods: Ninety-two female Sprague-Dawley (SD) rats were divided into 4 groups i.e. protamine sulfate (PS), N-acetylcysteine (NAC), and glucosamine-treated PS (GPS), and normal saline control (NC) were used. We induced hyperactivity in rats via intravesical infusion of PS and potassium chloride (KCl), whereas the NC group underwent a sustained intravesical saline infusion for 1 h. N-acetylcysteine (NAC), a potential antioxidant as well as anti-inflammatory agent was employed as positive control. Cystometrography (CMG) was then conducted to determine urodynamic parameters, i.e., leak point pressure (LPP, n = 48) and inter-contractile interval, the duration between two voids (ICI, n = 32). Results: LPP was significantly elevated in the GPS group (mean ± SD: 110.9 ± 6.2 mmHg) compared to the NC (81.0 ± 32.5 mmHg), PS (40.3 ± 10.9 mmHg), and NAC group (70.3 ± 19.4 mmHg). The cystometrogram data also reveals a prolonged ICI in the GPS group (241.3 ± 40.2 s) compared to the NC group (216.0 ± 41.7 s), PS group (128.8 ± 23.6 s), and NAC group (193.8 ± 28.3 s). Conclusion: This preliminary study implies the ameliorative impact of GPS treatment on OAB in terms of improved urodynamic parameters, including LPP and ICI. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة:	V105C-148 Taipei Veterans General Hospital
فهرسة مساهمة:	Keywords: Glucosamine; Inter-contraction interval; Leak-point pressure; Overactive bladder (OAB)
المشرفين على المادة:	0 (Protamines) 660YQ98I10 (Potassium Chloride) N08U5BOQ1K (Glucosamine)
تواريخ الأحداث:	Date Created: 20240711 Date Completed: 20240711 Latest Revision: 20240711
رمز التحديث:	20240711
DOI:	10.1007/s00345-024-05100-3
PMID:	38990380
قاعدة البيانات:	MEDLINE

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تدمد:	1433-8726
DOI:	10.1007/s00345-024-05100-3