دورية أكاديمية
A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases.
| العنوان: | A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases. |
|---|---|
| المؤلفون: | Beaver D; Clem Jones Centre for Regenerative Medicine, Bond University, Gold Coast, QL, Australia., Limnios IJ; Clem Jones Centre for Regenerative Medicine, Bond University, Gold Coast, QL, Australia. |
| المصدر: | Frontiers in transplantation [Front Transplant] 2023 Sep 29; Vol. 2, pp. 1130086. Date of Electronic Publication: 2023 Sep 29 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Country of Publication: Switzerland NLM ID: 9918573988006676 Publication Model: eCollection Cited Medium: Internet ISSN: 2813-2440 (Electronic) Linking ISSN: 28132440 NLM ISO Abbreviation: Front Transplant Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers, 2022- |
| مستخلص: | Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, photoreceptors, or a combination of both. Although stem cell-derived RPE cells have progressed to human clinical trials, therapies using photoreceptors and other retinal cell types are lagging. In this review, we discuss the potential use of human pluripotent stem cell (hPSC)-derived photoreceptors for the treatment of retinal degeneration and highlight the progress and challenges for their efficient production and clinical application in regenerative medicine. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Beaver and Limnios.) |
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| فهرسة مساهمة: | Keywords: cell therapy; human pluripotent stem cells; photoreceptors; regenerative medicine; retinal degeneration; retinal organoids |
| تواريخ الأحداث: | Date Created: 20240712 Latest Revision: 20240714 |
| رمز التحديث: | 20240714 |
| مُعرف محوري في PubMed: | PMC11235385 |
| DOI: | 10.3389/frtra.2023.1130086 |
| PMID: | 38993872 |
| قاعدة البيانات: | MEDLINE |
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