دورية أكاديمية
Comparative pathogenesis of three Mayaro virus genotypes in the cynomolgus macaque.
| العنوان: | Comparative pathogenesis of three Mayaro virus genotypes in the cynomolgus macaque. |
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| المؤلفون: | Hamilton MM; BIOQUAL Inc., Rockville, MD, 20852, USA., Webb EM; Department of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Peterson MC; BIOQUAL Inc., Rockville, MD, 20852, USA., Patel G; BIOQUAL Inc., Rockville, MD, 20852, USA., Porto M; BIOQUAL Inc., Rockville, MD, 20852, USA., Orekov T; BIOQUAL Inc., Rockville, MD, 20852, USA., Erasmus JH; HDT Bio, Seattle, WA, 98102, USA., Finneyfrock B; BIOQUAL Inc., Rockville, MD, 20852, USA., Cook A; BIOQUAL Inc., Rockville, MD, 20852, USA., Auguste AJ; Department of Entomology, College of Agriculture and Life Sciences, Fralin Life Science Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.; Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Kar S; BIOQUAL Inc., Rockville, MD, 20852, USA. |
| المصدر: | The Journal of general virology [J Gen Virol] 2024 Jul; Vol. 105 (7). |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 0077340 Publication Model: Print Cited Medium: Internet ISSN: 1465-2099 (Electronic) Linking ISSN: 00221317 NLM ISO Abbreviation: J Gen Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Microbiology Society Original Publication: London, Cambridge Univ. Press for the Society for General Microbiology. |
| مواضيع طبية MeSH: | Macaca fascicularis*/virology , Genotype* , Alphavirus*/genetics , Alphavirus*/pathogenicity , Alphavirus*/classification , Alphavirus*/isolation & purification , Alphavirus Infections*/virology , Alphavirus Infections*/veterinary , Viremia*/virology , RNA, Viral*/genetics, Animals ; Antibodies, Viral/blood ; Antibodies, Neutralizing/blood ; Disease Models, Animal ; Phylogeny ; Cytokines/genetics ; Cytokines/blood |
| مستخلص: | Mayaro virus (MAYV), a mosquito-borne alphavirus, is considered an emerging threat to public health with epidemic potential. Phylogenetic studies show the existence of three MAYV genotypes. In this study, we provide a preliminary analysis of the pathogenesis of all three MAYV genotypes in cynomolgus macaques ( Macaca facicularis , Mauritian origin). Significant MAYV-specific RNAemia and viremia were detected during acute infection in animals challenged intravenously with the three MAYV genotypes, and strong neutralizing antibody responses were observed. MAYV RNA was detected at high levels in lymphoid tissues, joint muscle and synovia over 1 month after infection, suggesting that this model could serve as a promising tool in studying MAYV-induced chronic arthralgia, which can persist for years. Significant leucopenia was observed across all MAYV genotypes, peaking with RNAemia. Notable differences in the severity of acute RNAemia and composition of cytokine responses were observed among the three MAYV genotypes. Our model showed no outward signs of clinical disease, but several major endpoints for future MAYV pathology and intervention studies are described. Disruptions to normal blood cell counts and cytokine responses were markedly distinct from those observed in macaque models of CHIKV infection, underlining the importance of developing non-human primate models specific to MAYV infection. |
| فهرسة مساهمة: | Keywords: MAYV pathogenesis; Mayaro virus; alphavirus; cynomolgus macaque; non-human primate model |
| المشرفين على المادة: | 0 (RNA, Viral) 0 (Antibodies, Viral) 0 (Antibodies, Neutralizing) 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240712 Latest Revision: 20240712 |
| رمز التحديث: | 20240713 |
| DOI: | 10.1099/jgv.0.002001 |
| PMID: | 38995674 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1465-2099 |
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| DOI: | 10.1099/jgv.0.002001 |