دورية أكاديمية
The role of cells and their derivatives in otorhinolaryngologic diseases treatment.
| العنوان: | The role of cells and their derivatives in otorhinolaryngologic diseases treatment. |
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| المؤلفون: | Ou H; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China., Yang Q; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China., Zhang Y; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China., Tang X; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China., Xiao M; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China., Li S; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China., Lei L; Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou 310015, Zhejiang, China. Electronic address: leilanjie1988@163.com., Xie Z; Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China. Electronic address: zuozhongxie@csu.edu.cn. |
| المصدر: | Life sciences [Life Sci] 2024 Sep 01; Vol. 352, pp. 122898. Date of Electronic Publication: 2024 Jul 11. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Otorhinolaryngologic Diseases*/therapy, Humans ; Animals ; Chondrocytes ; Exosomes/metabolism ; Cell- and Tissue-Based Therapy/methods ; Stem Cell Transplantation/methods ; Stem Cells |
| مستخلص: | Otolaryngology is an important specialty in the field of surgery that deals with the diagnosis and treatment of the ear, nose, throat, trachea, as well as related anatomical structures. Various otolaryngological disorders are difficult to treat using established pharmacological and surgical approaches. The advent of molecular and cellular therapies led to further progress in this respect. This article reviews the therapeutic strategies of using stem cells, immune cells, and chondrocytes in otorhinolaryngology. As the most widely recognized cell derivatives, exosomes were also systematically reviewed for their therapeutic potential in head and neck cancer, otitis media, and allergic rhinitis. Finally, we summarize the limitations of stem cells, chondrocytes, and exosomes, as well as possible solutions, and provide an outlook on the future direction of cell- and derivative-based therapies in otorhinolaryngology, to offer a theoretical foundation for the clinical translation of this therapeutic modality. Competing Interests: Declaration of competing interest The authors declare no competing financial interests related to this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chondrocytes; Exosomes; Mesenchymal stem cells; Otorhinolaryngologic diseases |
| تواريخ الأحداث: | Date Created: 20240712 Date Completed: 20240727 Latest Revision: 20240727 |
| رمز التحديث: | 20240728 |
| DOI: | 10.1016/j.lfs.2024.122898 |
| PMID: | 38997061 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2024.122898 |