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Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing.

التفاصيل البيبلوغرافية
العنوان: Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing.
المؤلفون: Lukyanov SA; Department of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia., Titov SE; Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk 630090, Russia.; PCR Laboratory, AO Vector-Best, Novosibirsk 630117, Russia.; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia., Kozorezova ES; National Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, Russia., Demenkov PS; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia.; Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia., Veryaskina YA; Department of the Structure and Function of Chromosomes, Institute of Molecular and Cellular Biology, SB RAS, Novosibirsk 630090, Russia.; Institute of Cytology and Genetics, SB RAS, Novosibirsk 630090, Russia., Korotovskii DV; Department of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia., Ilyina TE; Department of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia., Vorobyev SL; National Center of Clinical Morphological Diagnostics, Saint Petersburg 192283, Russia., Zhivotov VA; Department of Surgery, National Medical and Surgical Center Named after N.I. Pirogov, Moscow 105203, Russia., Bondarev NS; Department of Surgery, National Medical and Surgical Center Named after N.I. Pirogov, Moscow 105203, Russia., Sleptsov IV; Department of Faculty Surgery, Saint Petersburg State University, Saint Petersburg 199034, Russia., Sergiyko SV; Department of General and Pediatric Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 28; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Thyroid Cancer, Papillary*/genetics , Thyroid Cancer, Papillary*/pathology , Thyroid Cancer, Papillary*/diagnosis , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/diagnosis , Biomarkers, Tumor*/genetics , MicroRNAs*/genetics, Humans ; Biopsy, Fine-Needle ; Female ; Male ; Middle Aged ; Adult ; Proto-Oncogene Proteins B-raf/genetics ; Mutation ; Aged ; Fibronectins/genetics ; Fibronectins/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Gene Expression Regulation, Neoplastic ; Prognosis
مستخلص: Molecular genetic events are among the numerous factors affecting the clinical course of papillary thyroid carcinoma (PTC). Recent studies have demonstrated that aberrant expression of miRNA, as well as different thyroid-related genes, correlate with the aggressive clinical course of PTC and unfavorable treatment outcomes, which opens up new avenues for using them in the personalization of the treatment strategy for patients with PTC. In the present work, our goal was to assess the applicability of molecular markers in the preoperative diagnosis of aggressive variants of papillary thyroid cancer. The molecular genetic profile (expression levels of 34 different markers and BRAF mutations) was studied for 108 cytology specimens collected by fine-needle aspiration biopsy in patients with PTC having different clinical manifestations. Statistically significant differences with adjustment for multiple comparisons ( p < 0.0015) for clinically aggressive variants of PTC were obtained for four markers: miRNA-146b, miRNA-221, fibronectin 1 (FN1), and cyclin-dependent kinase inhibitor 2A (CDKN2A) genes. A weak statistical correlation (0.0015 < p < 0.05) was observed for miRNA-31, -375, -551b, -148b, -125b, mtDNA, CITED1, TPO, HMGA2, CLU, NIS, SERPINA1, TFF3, and TMPRSS4. The recurrence risk of papillary thyroid carcinoma can be preoperatively predicted using miRNA-221, FN1, and CDKN2A genes.
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معلومات مُعتمدة: 20-14-00074-P Russian Science Foundation
فهرسة مساهمة: Keywords: CDKN2A; FN1; aggressive variants; miRNA-146b; miRNA-221; papillary thyroid carcinoma; recurrence risk
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (MicroRNAs)
EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
0 (Fibronectins)
0 (FN1 protein, human)
EC 2.7.11.1 (BRAF protein, human)
0 (Cyclin-Dependent Kinase Inhibitor p16)
تواريخ الأحداث: Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC11241318
DOI: 10.3390/ijms25137090
PMID: 39000197
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25137090