دورية أكاديمية
Hypothalamic and hippocampal transcriptome changes in App NL-G-F mice as a function of metabolic and inflammatory dysfunction.
| العنوان: | Hypothalamic and hippocampal transcriptome changes in App NL-G-F mice as a function of metabolic and inflammatory dysfunction. |
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| المؤلفون: | Gutiérrez Rico E; Tohoku University, Graduate School of Pharmaceutical Sciences, Sendai 980-8578, Japan., Joseph P; SUNY Old Westbury, 223 Store Hill Rd, Old Westbury, NY 11568, USA., Noutsos C; SUNY Old Westbury, 223 Store Hill Rd, Old Westbury, NY 11568, USA., Poon K; SUNY Old Westbury, 223 Store Hill Rd, Old Westbury, NY 11568, USA. Electronic address: poonk@oldwestbury.edu. |
| المصدر: | Neuroscience [Neuroscience] 2024 Aug 30; Vol. 554, pp. 107-117. Date of Electronic Publication: 2024 Jul 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| مواضيع طبية MeSH: | Hippocampus*/metabolism , Hypothalamus*/metabolism , Mice, Transgenic* , Alzheimer Disease*/metabolism , Alzheimer Disease*/genetics , Transcriptome*, Animals ; Male ; Mice ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Inflammation/metabolism ; Cognitive Dysfunction/metabolism |
| مستخلص: | The progression of Alzheimer's disease (AD) has a silent phase that predates characteristic cognitive decline and eventually leads to active cognitive deficits. Metabolism, diet, and obesity have been correlated to the development of AD but is poorly understood. The hypothalamus is a brain region that exerts homeostatic control on food intake and metabolism and has been noted to be impacted during the active phase of Alzheimer's disease. This study, in using an amyloid overexpression App NL-G-F mouse model under normal metabolic conditions, examines blood markers in young and old male App NL-G-F mice (n = 5) that corresponds to the silent and active phases of AD, and bulk gene expression changes in the hypothalamus and the hippocampus. The results show a large panel of inflammatory mediators, leptin, and other proteins that may be involved in weakening the blood brain barrier, to be increased in the young App NL-G-F mice but not in the old App NL-G-F mice. There were also several differentially expressed genes in both the hypothalamus and the hippocampus in the young App NL-G-F mice prior to amyloid plaque formation and cognitive decline that persisted in the old App NL-G-F mice, including GABRa2 receptor, Wdfy1, and several pseudogenes with unknown function. These results suggests that a larger panel of inflammatory mediators may be used as blood markers to detect silent AD, and that a change in leptin and gene expression in the hypothalamus exist prior to cognitive effects, suggesting a coupling of metabolism with amyloid plaque induced cognitive decline. (Copyright © 2024 IBRO. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; App(NL-G-F); Hypothalamus; Inflammation; Metabolism |
| المشرفين على المادة: | 0 (Amyloid beta-Protein Precursor) |
| تواريخ الأحداث: | Date Created: 20240713 Date Completed: 20240814 Latest Revision: 20240814 |
| رمز التحديث: | 20240815 |
| DOI: | 10.1016/j.neuroscience.2024.07.007 |
| PMID: | 39002757 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-7544 |
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| DOI: | 10.1016/j.neuroscience.2024.07.007 |