دورية أكاديمية
99m Tc-HFAPi SPECT imaging predicts left ventricular remodeling after acute myocardial infarction.
| العنوان: | 99m Tc-HFAPi SPECT imaging predicts left ventricular remodeling after acute myocardial infarction. |
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| المؤلفون: | Hua C; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Xi XY; Department of Nuclear Medicine, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Zhang Y; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Suo N; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Tu B; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Liu Y; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Yang X; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Liu X; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Su P; Department of Cardiac Surgery, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Xie B; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Yang M; Department of Nuclear Medicine, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China., Wang Y; Department of Cardiology, Cardiovascualr Imaging Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: yfwyj@163.com. |
| المصدر: | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2024 Aug; Vol. 38, pp. 101910. Date of Electronic Publication: 2024 Jul 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: St. Louis, MO : Mosby-Year Book, Inc., c1994- |
| مواضيع طبية MeSH: | Ventricular Remodeling* , Myocardial Infarction*/diagnostic imaging , Tomography, Emission-Computed, Single-Photon*, Humans ; Male ; Female ; Middle Aged ; Aged ; Radiopharmaceuticals ; Echocardiography/methods ; Organotechnetium Compounds ; Cohort Studies |
| مستخلص: | Background: Despite improved treatments for acute myocardial infarction (AMI), myocardial fibrosis remains a key driver of adverse left ventricular (LV) remodeling and increased mortality. Fibroblast activation and proliferation significantly contribute to this process by enhancing cardiac fibrosis, which can lead to detrimental changes in LV structure. This study evaluates the effectiveness of 99m Tc-labeled fibroblast activation protein inhibitor ( 99m Tc-HFAPi) SPECT imaging in predicting LV remodeling over 12 months in post-AMI patients. Methods: A cohort of 58 AMI patients (46 males, median age 61 [53, 67] years) underwent baseline 99m Tc-HFAPi imaging (5 ± 2 days post-MI), perfusion imaging (6 ± 2 days post-MI), and echocardiography (2 ± 2 days post-MI). Additionally, 15 patients had follow-up 99m Tc-HFAPi and perfusion imaging, while 30 patients had follow-up echocardiography. Myocardial 99m Tc-HFAPi activity was assessed at the patient level. LV remodeling was defined as a ≥10% increase in LV end-diastolic diameter (LVEDD) or LV end-systolic diameter (LVESD) from baseline to follow-up echocardiography. Results: AMI patients displayed localized but non-uniform 99m Tc-HFAPi uptake, exceeding perfusion defects. Baseline 99m Tc-HFAPi activity exhibited significant correlations with BNPmax, LDHmax, cTNImax, and WBCmax, inversely correlating with LVEF. After 12 months, 11 patients (36.66%) experienced LV remodeling. Univariate regression analysis demonstrated an association between baseline 99m Tc-HFAPi uptake extent and LV remodeling (OR = 2.14, 95%CI, 1.04, 4.39, P = 0.038). Conclusions: 99m Tc-HFAPi SPECT imaging holds promise in predicting LV remodeling post-MI, providing valuable insights for patient management and prognosis. (Copyright © 2024 American Society of Nuclear Cardiology. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: (99m)Tc-HFAPi; Fibroblast activation protein; Left ventricular remodeling; Myocardial infarction; Prognosis |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) 0 (Organotechnetium Compounds) |
| تواريخ الأحداث: | Date Created: 20240715 Date Completed: 20240831 Latest Revision: 20240901 |
| رمز التحديث: | 20240902 |
| DOI: | 10.1016/j.nuclcard.2024.101910 |
| PMID: | 39009216 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-6551 |
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| DOI: | 10.1016/j.nuclcard.2024.101910 |