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A Single-Dose mRNA Vaccine Employing Porous Silica Nanoparticles Induces Robust Immune Responses Against the Zika Virus.

التفاصيل البيبلوغرافية
العنوان: A Single-Dose mRNA Vaccine Employing Porous Silica Nanoparticles Induces Robust Immune Responses Against the Zika Virus.
المؤلفون: Shin H; Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea., Kang S; Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea., Won C; Institute of Biotherapeutics Convergence Technology, Lemonex Inc., Seoul, 06683, Republic of Korea., Min DH; Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea.; Institute of Biotherapeutics Convergence Technology, Lemonex Inc., Seoul, 06683, Republic of Korea.
المصدر: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Sep; Vol. 11 (35), pp. e2404590. Date of Electronic Publication: 2024 Jul 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim : WILEY-VCH, [2014]-
مواضيع طبية MeSH: Silicon Dioxide*/chemistry , Nanoparticles*/chemistry , Zika Virus*/immunology , Zika Virus Infection*/immunology , Zika Virus Infection*/prevention & control , Mice, Inbred C57BL* , mRNA Vaccines*/immunology , Viral Vaccines*/immunology , Viral Vaccines*/administration & dosage, Animals ; Mice ; Disease Models, Animal ; Porosity ; Female ; RNA, Messenger/immunology ; RNA, Messenger/genetics ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology
مستخلص: Recently, lipid nanoparticles (LNPs)-based mRNA delivery has been approved by the FDA for SARS-CoV-2 vaccines. However, there are still considerable points for improvement in LNPs. Especially, local administration of LNPs-formulated mRNA can cause off-target translation of mRNA in distal organs which can induce unintended adverse effects. With the hypothesis that large and rigid nanoparticles can be applied to enhance retention of nanoparticles at the injection site, a polyethyleneimine (PEI)-coated porous silica nanoparticles (PPSNs)-based mRNA delivery platform is designed. PPSNs not only facilitate localized translation of mRNA at the site of injection but also prolonged protein expression. It is further demonstrated that the development of a highly efficacious Zika virus (ZIKV) vaccine using mRNA encoding full-length ZIKV pre-membrane (prM) and envelope (E) protein delivered by PPSNs. The ZIKV prME mRNA-loaded PPSNs vaccine elicits robust immune responses, including high levels of neutralizing antibodies and ZIKV E-specific T cell responses in C57BL/6 mice. Moreover, a single injection of prME-PPSNs vaccine provided complete protection against the ZIKV challenge in mice.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
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معلومات مُعتمدة: Lemonex Inc
فهرسة مساهمة: Keywords: local delivery; mRNA vaccine; porous silica nanoparticles; virus vaccine; zika virus
المشرفين على المادة: 7631-86-9 (Silicon Dioxide)
0 (mRNA Vaccines)
0 (Viral Vaccines)
0 (RNA, Messenger)
0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
تواريخ الأحداث: Date Created: 20240716 Date Completed: 20240926 Latest Revision: 20240928
رمز التحديث: 20240928
مُعرف محوري في PubMed: PMC11425238
DOI: 10.1002/advs.202404590
PMID: 39010673
قاعدة البيانات: MEDLINE
الوصف
تدمد:2198-3844
DOI:10.1002/advs.202404590