دورية أكاديمية
The Potential Role of the Leucocyte Immunoglobulin-Like Receptors in Kidney Transplant Rejection: A Mini Review.
| العنوان: | The Potential Role of the Leucocyte Immunoglobulin-Like Receptors in Kidney Transplant Rejection: A Mini Review. |
|---|---|
| المؤلفون: | Palvair J; Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France., Farhat I; Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France.; Centre Hospitalier Universitaire de Dijon, Service de Néphrologie et Transplantation Rénale, Université de Bourgogne, Dijon, France., Chaintreuil M; Centre Hospitalier Universitaire de Dijon, Service de Néphrologie et Transplantation Rénale, Université de Bourgogne, Dijon, France., Dal Zuffo L; Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France., Messager L; Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France., Tinel C; Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France.; Centre Hospitalier Universitaire de Dijon, Service de Néphrologie et Transplantation Rénale, Université de Bourgogne, Dijon, France., Lamarthée B; Université de Franche-Comté, EFS, INSERM, UMR RIGHT, Besançon, France. |
| المصدر: | Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2024 Jul 01; Vol. 37, pp. 12995. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 8908516 Publication Model: eCollection Cited Medium: Internet ISSN: 1432-2277 (Electronic) Linking ISSN: 09340874 NLM ISO Abbreviation: Transpl Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Lausanne, Switzerland : Frontiers Media S. A. Original Publication: [Heidelberg, FRG] : Springer International, 1988- |
| مواضيع طبية MeSH: | Graft Rejection*/immunology , Kidney Transplantation*/adverse effects , Receptors, Immunologic*/immunology, Humans ; Animals ; Mice ; HLA Antigens/immunology ; Monocytes/immunology ; Antigens, CD/immunology ; Macrophages/immunology |
| مستخلص: | Antibody-mediated rejection (ABMR) remains one of the main causes of long-term graft failure after kidney transplantation, despite the development of powerful immunosuppressive therapy. A detailed understanding of the complex interaction between recipient-derived immune cells and the allograft is therefore essential. Until recently, ABMR mechanisms were thought to be solely caused by adaptive immunity, namely, by anti-human leucocyte antigen (HLA) donor-specific antibody. However recent reports support other and/or additive mechanisms, designating monocytes/macrophages as innate immune contributors of ABMR histological lesions. In particular, in mouse models of experimental allograft rejection, monocytes/macrophages are readily able to discriminate non-self via paired immunoglobulin receptors (PIRs) and thus accelerate rejection. The human orthologs of PIRs are leukocyte immunoglobulin-like receptors (LILRs). Among those, LILRB3 has recently been reported as a potential binder of HLA class I molecules, shedding new light on LILRB3 potential as a myeloid mediator of allograft rejection. In this issue, we review the current data on the role of LILRB3 and discuss the potential mechanisms of its biological functions. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Palvair, Farhat, Chaintreuil, Dal Zuffo, Messager, Tinel and Lamarthée.) |
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| فهرسة مساهمة: | Keywords: LILRs; allograft rejection; innate immunity; kidney transplant; monocyte |
| المشرفين على المادة: | 0 (Receptors, Immunologic) 0 (LILRB3 protein, human) 0 (HLA Antigens) 0 (Antigens, CD) |
| تواريخ الأحداث: | Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240717 |
| رمز التحديث: | 20240717 |
| مُعرف محوري في PubMed: | PMC11247310 |
| DOI: | 10.3389/ti.2024.12995 |
| PMID: | 39010891 |
| قاعدة البيانات: | MEDLINE |
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