دورية أكاديمية
Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.
| العنوان: | Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity. |
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| المؤلفون: | Huang S; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Program in Neuroscience, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rizzo D; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wu SJ; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xu Q; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia.; Past address: Center for Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE., Ziane L; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Alghamdi N; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia., Stafford DA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94708, USA., Daigle TL; Allen Institute for Brain Science, Seattle, WA 98109, USA., Tasic B; Allen Institute for Brain Science, Seattle, WA 98109, USA., Zeng H; Allen Institute for Brain Science, Seattle, WA 98109, USA., Ibrahim LA; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Kingdom of Saudi Arabia., Fishell G; Harvard Medical School, Blavatnik Institute, Department of Neurobiology, Boston, MA 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. |
| المصدر: | Research square [Res Sq] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02. |
| نوع المنشور: | Journal Article; Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| مستخلص: | Neurogliaform cells are a distinct type of GABAergic cortical interneurons known for their 'volume transmission' output property. However, their activity and function within cortical circuits remain unclear. Here, we developed two genetic tools to target these neurons and examine their function in the primary visual cortex. We found that the spontaneous activity of neurogliaform cells positively correlated with locomotion. Silencing these neurons increased spontaneous activity during locomotion and impaired visual responses in L2/3 pyramidal neurons. Furthermore, the contrast-dependent visual response of neurogliaform cells varies with their laminar location and is constrained by their morphology and input connectivity. These findings demonstrate the importance of neurogliaform cells in regulating cortical behavioral state-dependent spontaneous activity and indicate that their functional engagement during visual stimuli is influenced by their laminar positioning and connectivity. Competing Interests: Additional Declarations: Yes there is potential Competing Interest. The senior author is a founder of Regel Therapeutics |
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| معلومات مُعتمدة: | P01 NS074972 United States NS NINDS NIH HHS; P30 NS072030 United States NS NINDS NIH HHS; UG3 MH120096 United States MH NIMH NIH HHS; R37 MH071679 United States MH NIMH NIH HHS; R01 NS081297 United States NS NINDS NIH HHS |
| تواريخ الأحداث: | Date Created: 20240716 Latest Revision: 20240723 |
| رمز التحديث: | 20240723 |
| مُعرف محوري في PubMed: | PMC11247929 |
| DOI: | 10.21203/rs.3.rs-4530873/v1 |
| PMID: | 39011116 |
| قاعدة البيانات: | MEDLINE |
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