دورية أكاديمية
Effect of hydrogen peroxide and hyaluronic acid in mouth rinse after third molar extraction: a triple-blind parallel randomized controlled clinical trial.
| العنوان: | Effect of hydrogen peroxide and hyaluronic acid in mouth rinse after third molar extraction: a triple-blind parallel randomized controlled clinical trial. |
|---|---|
| المؤلفون: | Boccalari E; Department of Biomedical, Surgical, and Dental Science, University of Milan, Milan, Italy. gianluca.tartaglia@unimi.it., Khijmatgar S, Occhipinti C, Del Fabbro M, Inchingolo F, Tartaglia GM |
| المصدر: | European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2024 Jul; Vol. 28 (13), pp. 3946-3957. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verduci Country of Publication: Italy NLM ID: 9717360 Publication Model: Print Cited Medium: Internet ISSN: 2284-0729 (Electronic) Linking ISSN: 11283602 NLM ISO Abbreviation: Eur Rev Med Pharmacol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rome : Verduci, [1997- |
| مواضيع طبية MeSH: | Hyaluronic Acid*/administration & dosage , Mouthwashes*/administration & dosage , Molar, Third*/surgery , Hydrogen Peroxide*/administration & dosage , Tooth Extraction*/adverse effects, Humans ; Adult ; Female ; Male ; Young Adult ; Wound Healing/drug effects |
| مستخلص: | Objective: The study aimed to investigate the potential beneficial role of hydrogen peroxide (H2O2) and hyaluronic acid (HA) combination formulation in socket healing after third molar surgery. Biomaterials, including mouthwash formulations, were hypothesized to contribute to improved socket healing and reduced post-operative complications. Patients and Methods: A triple-blinded parallel randomized controlled clinical trial was conducted at a single-center dental hospital in Milan, Italy. The trial included 114 patients who underwent extraction of impacted, partially erupted, and completely erupted third molars. Patients were randomly assigned to three parallel groups: Group 1 (H2O2 and HA), Group 2 (placebo), and Group 3 (0.2% chlorhexidine). The trial was registered at ClinicalTrial.gov (registration number NCT04438434). The main outcome measures included various parameters related to socket healing, such as pain, inflammation, swelling, plaque index, bleeding index, granulation tissue, suppuration, re-epithelialization, bleeding upon palpation, odor, and taste alteration. Patients were followed up for 7 days. Results: All 114 enrolled patients completed the study, with no dropouts or loss to follow-up. The mean age of patients in the three groups differed (H2O2 and HA: 30.9±14.9; placebo: 27.6±13.1; 0.2% chlorhexidine: 23.05±10.16). Significant reductions (p<0.001) in visual analog scale (VAS) pain levels and other outcome measures were observed in the H2O2 and HA group compared to the placebo group. These findings suggest a positive effect of the H2O2 and HA combination on socket healing after the third molar surgery. Conclusions: The study concludes that the combination of hydrogen peroxide and hyaluronic acid can be considered a potential mouthwash with beneficial effects on socket healing following third molar surgery. However, additional clinical trials are recommended to validate its effectiveness further and provide additional evidence supporting its use in clinical settings. Clinicaltrial: gov: NCT04438434. |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04438434 |
| المشرفين على المادة: | 9004-61-9 (Hyaluronic Acid) 0 (Mouthwashes) BBX060AN9V (Hydrogen Peroxide) |
| تواريخ الأحداث: | Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240716 |
| رمز التحديث: | 20240716 |
| DOI: | 10.26355/eurrev_202407_36527 |
| PMID: | 39012233 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!